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  • 154563 - Tris(hydroxymethyl)aminomethane

154563 Aldrich


ultrapure grade, ≥99.9%

Synonym: 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol



grade   ultrapure grade
assay   ≥99.9%
useful pH range   7 - 9
pKa (25 °C)   8.1
bp   219-220 °C/10 mmHg(lit.)
mp   167-172 °C(lit.)


Frequently Asked Questions

Frequently Asked Questions are available for this Product.


Buffer and primary pH standard. pKa=8.3 at 20°C. Auxiliary material in pharmaceutical science.

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Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
What does the "ultrapure grade" in the description of Product 154563, Tris(hydroxymethyl)aminomethane, indicate?
This material has been specifically purified to have the lowest heavy metals and iron content.
What solvents can be used to dissolve Product T54563, Trometamol?
According to the Merck Index (which we also offer as Product No. Z705322), this material is expected to be soluble in water (550 mg/mL), ethylene glycol (79.1 mg/mL), methanol (26 mg/mL), anhydrous ethanol (14.6 mg/mL), 95% ethanol (22 mg/mL), dimethylformamide (14mg/mL) and acetone (2mg/mL) at room temperature.
Where can I find more technical information on Product T54563, Trometamol, and other buffers?
Please visit the Learning Center in our Buffer Explorer section of the website. There you will find helpful formulas, buffer calculator tools and other property information on our buffer products. This resource is available through the following link. http://www.sigmaaldrich.com/Area_of_Interest/Biochemicals/Buffer_Explorer.html
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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