|Related Categories||Amino Acid Derivatives, Chemical Biology, Chemical Synthesis, Cysteine/Cystine, Peptide Chemistry More...|
|optical activity||[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl|
|mp||182-183 °C (dec.)(lit.)|
Protected cysteine for peptide synthesis.
5 g in glass bottle
Certificate of Analysis
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. Good JA, Wang F, Rath O, et al. J. Med. Chem. 56(5), 1878-93, (2013)
High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture(SILAC), two-dimensional gel electrophoresis(2DE) and nano-liquid chromatograpohy coupled to an LTQ-OrbitrapMass spectrometer. Thiede B, Koehler CJ, Strozynski M, et al. Mol. Cell. Proteomics 12(2), 529-38, (2013)
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine. Abualhasan MN, Good JA, Wittayanarakul K, et al. Eur. J. Med. Chem. 54, 483-98, (2012)
Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines. Tcherniuk S, van Lis R, Kozielski F, et al. Biochem. Pharmacol. 79(6), 864-72, (2010)
Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest. Casado P, Prado MA, Zuazua-Villar P, et al. J. Proteomics 71(6), 592-600, (2009)
Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5. Kozielski F, Skoufias DA, Indorato RL, et al. Proteomics 8(2), 289-300, (2008)
Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly. Jiang C, Chen Y, Wang X, et al. J. Mol. Model. 13(9), 987-92, (2007)
Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents. Brier S, Lemaire D, DeBonis S, et al. J. Mol. Biol. 360(2), 360-76, (2006)
FT-IR 2 (2), 2746:B / FT-IR 1 (2), 251:D / IR-Spectra (2), 871:G / IR-Spectra (3), 995:H / NMR-Reference 2 (2), 264:B / RegBook 1 (2), 1843:G / Sigma FT-IR 1 (1), 274:B / Structure Index 1, 295:B:6
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