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183954 Aldrich

1,4-Dithiane-2,5-diol

97%

Synonym: 2,5-Dihydroxy-1,4-dithiane, Mercaptoacetaldehyde dimer

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Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Other Heterocyclic Building Blocks, S-Containing More...
InChI Key   YUIOPHXTILULQC-UHFFFAOYSA-N
assay   97%
mp   130 °C (dec.)(lit.)
storage temp.   2-8°C

Description

Packaging

50, 250 g in glass bottle

Application

1,4-Dithiane-2,5-diol was used in the synthesis of:
• substituted tetrahydrothiophene derivatives
• 2-amino-3-(arylsulfonyl)thiophenes, potential antiviral and antitumor agents

General description

1,4-Dithiane-2,5-diol undergoes bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction with chalcones to afford trisubstituted tetrahydrothiophenes. It participates in diastereoselective [3+3] cycloaddition with azomethine imines catalyzed by 1,4-diazabicyclo[2.2.2]octane. It is a mercaptoacetaldehyde dimer and an efficient synthon for incorporating a thiol group to in situ generated nitroalkenes.

Price and Availability

Suggested Laboratory Gloves


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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3335
WGK Germany 
2
Protocols & Articles
Peer-Reviewed Papers
15

References

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