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18565 Aldrich

Bromotripyrrolidinophosphonium hexafluorophosphate

≥95.0% (HPLC)

Synonym: PyBroP®

  • CAS Number 132705-51-2

  • Empirical Formula (Hill Notation) C12H24BrF6N3P2

  • Molecular Weight 466.18

  •  Beilstein Registry Number 6842340

  •  MDL number MFCD00077412

  •  PubChem Substance ID 24851154

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling,
InChI Key   CYKRMWNZYOIJCH-UHFFFAOYSA-N
assay   ≥95.0% (HPLC)
storage temp.   −20°C

Description

Other Notes

Reactive peptide coupling reagent suitable for α,α-dialkyl amino acids; Synthesis of depsipeptides

Packaging

1 g in poly tube

5, 25 g in poly bottle

Application

Catalyst for:
Synthesis of primary amides
Direct dehydrative phosphonium cross coupling
Direct arylation
Pyrrolidide formation by phosphonium salt coupling reagents

Legal Information

PyBroP is a registered trademark of Merck KGaA, Darmstadt, Germany

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Phosphonium Salts

Phosphonium salts are powerful and easy-to-use peptide coupling reagents that allow in situ generation of active esters. After the recognition of chlorotris(dimethylamino)phosphonium as the activatin...
Matthias Junkers
Aldrich ChemFiles 2007, 7.2, 8.
Keywords: Chemfiles, Peptide synthesis

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COMU – Safer and More Efficient Peptide Coupling Reagent

Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Catalog, Condensations, Coupling reactions, Epimerizations, Methods, PEGylations, Peptide synthesis, Protocols, Racemizations, Search, Solid phase peptide synthesis, Solvents, Tools

Peer-Reviewed Papers
15

References

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