|Related Categories||Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling,|
Reactive peptide coupling reagent suitable for α,α-dialkyl amino acids5; Synthesis of depsipeptides6
1 g in poly tube
5, 25 g in poly bottle
Synthesis of primary amides1
Direct dehydrative phosphonium cross coupling2
Pyrrolidide formation by phosphonium salt coupling reagents4
PyBroP is a registered trademark of Merck KGaA
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Certificate of Analysis
|Precautionary statements||P280-P305 + P351 + P338-P310|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||C|
|Risk Statements (Europe)||34|
|Safety Statements (Europe)||26-27-36/37/39-45|
Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Condensations, Coupling reactions, Epimerizations, PEGylations, Peptide synthesis, Racemizations, Solid phase peptide synthesis, Solvents
1. Vassiliki Theodorou, et al Tetrahedron 67, 5630-5634, (2011)
4. Jordi Alsina, et al Lett. Pept. Sci. 6, 243-245, (1999)
5. J. Coste et al. J. Org. Chem. 59, 2437, (1994)
6. T. Kurome et al. Tetrahedron 52, 4327, (1996)
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