1-Methylindole ≥97% | Sigma-Aldrich

Properties

Related Categories	Building Blocks, C7 to C9, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
assay	≥97%
refractive index	n20/D 1.606(lit.)
bp	133 °C/26 mmHg(lit.)
density	1.051 g/mL at 20 °C(lit.)

Description

Packaging

5, 25 g in glass bottle

Application

Reactant for preparation of:
• Pharmaceutically active 2-oxo-1-pyrrolidine analogues¹
• Non-receptor tyrosine kinase (Src kinase) inhibitors²
• PET agents for imaging of protein kinase C (PKC)³
• Ynediones as highly reactive Michael systems⁴
• Anticancer agents⁵
• Polycyclic derivatives of indoles⁶
• PET agents for imaging of glycogen synthase kinase-3 (GSK-3)⁷
• Anti-prion disease agents⁸
• Bisindole derivatives with antihyperlipidemic activity⁹
• PET cancer imaging agents¹⁰

Price and Availability

Related Papers

1. Direct alkylation of indoles and amines by tert-enamides: facile access to pharmaceutically active 2-oxo-1-pyrrolidine analogues. Jiang, R.; et al. Org. Biomol. Chem. 9, 5659, (2011)

Documents

Certificate of Analysis

Certificate of Origin

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

Pressure-Temperature Nomograph

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
WGK Germany	3
Flash Point(F)	235.4 °F
Flash Point(C)	113 °C

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

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1. Direct alkylation of indoles and amines by tert-enamides: facile access to pharmaceutically active 2-oxo-1-pyrrolidine analogues. Jiang, R.; et al. Org. Biomol. Chem. 9, 5659, (2011)

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2. 3-substitued indoles: one-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities. Rao, V. K.; et al. Bioorg. Med. Chem. Lett. 21, 3511, (2011)

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3. [11C]enzastaurin, the first design and radiosynthesis of a new potential PET agent for imaging of protein kinase C. Wang, M.; et al. Bioorg. Med. Chem. Lett. 21, 1649, (2011)

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4. Three-component synthesis of ynediones by a glyoxylation/Stephens-Castro coupling sequence. Merkul, E.; et al. Angew. Chem. Int. Ed. Engl. 50, 2966, (2011)

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5. Synthesis of novel indolyl-1,2,4-triazoles as potent and selective anticancer agents. Kumar, D.; et al. Chem. Biol. Drug Des. 77, 182, (2011)

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6. Chernyak, N.; et al. ARKIVOC, 76, (2011)

7. The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3). Wang, M.; et al. Bioorg. Med. Chem. Lett. 21, 245, (2011)

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8. Structure-activity relationship refinement and further assessment of indole-3-glyoxylamides as a lead series against prion disease. Thompson, M. J.; et al. ChemMedChem 6, 115, (2011)

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9. Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives. Sashidhara, K. V.; et al. Bioorg. Med. Chem. Lett. 20, 6504, (2010)

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10. The first design and synthesis of [11C]MKC-1 ([11C]Ro 31-7453), a new potential PET cancer imaging agent. Wang, M.; et al. Nucl. Med. Biol. 37, 763, (2010)

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Beil. 20,V,7,12

FT-IR 1 (2), 653:B / FT-IR 2 (3), 3570:B / FT-NMR 1 (3), 121:B / IR-Spectra (3), 1242:B / NMR-Reference 2 (2), 519:B / RegBook 1 (2), 2401:B / Sigma FT-IR 1 (2), 737:A / Structure Index 1, 381:B:1 / Vapor Phase 3, 1497:B

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1-Methylindole

≥97%

Properties

Description

Packaging

Application

Price and Availability

Related Papers

Documents

Safety Information

Papers

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