Boron tribromide solution 1.0 M in methylene chloride

Properties

Related Categories	25mL Sure/Seal Reagents, Chemical Synthesis, Deprotecting Reagents, Organometallic Reagents, Others, Protection and Derivatization, Synthetic Reagents More...
concentration	1.0 M in methylene chloride
density	1.467 g/mL at 25 °C

Description

Application

Used to cleave aryl methyl ethers in a synthesis of a benzopyranobenzopyran from a coumarin scaffold.¹¹

Reactant for preparation of:
• Drug intermediate 6-nitro-L-DOPA¹
• Luminescent polystyrene derivatives with sterically protected carbazolylborane moieties²
• High-quality boron-doped graphene via Wurtz-type reductive coupling reaction³
• Mercapto-(+)-methamphetamine haptens for synthesis of (+)-methamphetamine conjugate vaccines with improved epitope densities⁴
• Micrometer-sized organic molecule-DNA hybrid structures⁵
• Borane complexes via electrophilic aromatic borylation reactions⁶
• A 5-HT2C receptor agonist⁷
• Biphenyl-derivatives possessing tertiary amino groups as ß-secretase(BACE1) inhibitors for the treatment of Alzheimer′s disease⁸
• A highly near-IR region fluorescent p-extended boron aza-dipyrromethene moiety unit⁹
• Tetrahydroisoquinoline derivatives via intramolecular cyclization of methoxy-substituted N-phenethylimides¹⁰

Packaging

10 mL in glass bottle

2 L in Sure/Seal™

2.5 L in glass bottle

4×25, 100, 800 mL in Sure/Seal™

Price and Availability

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Related Papers

4. Synthesis of mercapto-(+)-methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines. Carroll, F. I.; et al. J. Med. Chem. 54, 5221, (2011)

Documents

Certificate of Analysis

Certificate of Origin

ChemFiles Vol 7 No 3 (1 MB )

Safety Information

Symbol	GHS05, GHS06, GHS08
Signal word	Danger
Hazard statements	H300-H314-H330-H351
Precautionary statements	P260-P264-P280-P284-P301 + P310-P305 + P351 + P338
Supplemental Hazard Statements	Reacts violently with water.
Personal Protective Equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes (Europe)	T+
Risk Statements (Europe)	14-26/28-35-40
Safety Statements (Europe)	26-28-36/37/39-45
RIDADR	UN 3390 6.1/PG 1
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Acids and Bases

Acids and bases have been used by chemists for centuries, and are among the most fundamental reagents employed in synthetic organic chemistry. This Aldrich product line ranges from Brønsted and Lewis...
Chemfiles Volume 1 Article 3

Papers

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1. Wu, C; et al. He Cheng Hua Xue 19, 418, (2011)

2. Parab, K.; et al. Macromolecules 44, 5961, (2011)

3. Lue, X.; et al. J. Mater. Chem. 21, 10685, (2011)

4. Synthesis of mercapto-(+)-methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines. Carroll, F. I.; et al. J. Med. Chem. 54, 5221, (2011)

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5. Syntheses of organic molecule-DNA hybrid structures. Lee, J. K.; et al. ACS Nano 5, 2067, (2011)

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6. Synthesis of pyridine-borane complexes via electrophilic aromatic borylation. Ishida, N.; et al. J. Org. Chem. 75, 8709, (2010)

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7. Gontcharov, A.; et al. Org. Process Res. Dev. 14, 1446, (2010)

8. Bertini, S.; et al. Lett. Drug Des. Discov. 7, 507, (2010)

9. Kataoka, Y.; et al. Chem. Lett. 39, 953, (2010)

10. An unusual reactivity of BBr(3): Accessing tetrahydroisoquinoline units from N-phenethylimides. Selvakumar, J.; et al. Org. Biomol. Chem. 8, 4056, (2010)

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11. Tetrahedron Lett. 47, 5909, (2006)

Merck 14,1347

Fieser 1,66 / Fieser 2,33 / Fieser 3,30 / Fieser 4,42 / Fieser 5,49 / Fieser 6,64 / Fieser 9,61 / Fieser 10,50 / Fieser 13,43 / Fieser 14,53