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211672 Aldrich

Nipecotic acid

98%

Synonym: (±)-β-Homoproline, 3-Piperidinecarboxylic acid, 3-Carboxypiperidine, Hexahydronicotinic acid

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Properties

Related Categories Building Blocks, C5 to C7, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis,
InChI Key   XJLSEXAGTJCILF-UHFFFAOYSA-N
assay   98%
mp   261 °C (dec.)(lit.)
solubility   water: soluble50 mg/mL, clear, colorless to faintly yellow
Gene Information   human ... SLC23A2(9962)

Description

Packaging

1, 5, 25 g in poly bottle

Application

Nipecotic acid was used in determination of the antiepileptic drug vigabatrin and the amino acid neurotransmitters in rat brain extracellular fluid by capillary electrophoresis with laser-induced fluorescence detection.

Reactant for concurrent esterification and N-acteylation of amino acids with orthoesters

Reactant for synthesis of:
Anticonvulsants
HCV NS5B polymerase inhibitors
Cathepsin S inhibitors
Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Positive allosteric modulator of metabotropic glutamate receptor 4

General description

R(−)-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 211672.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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