Nipecotic acid

Papers

1. Concurrent esterification and N-acetylation of amino acids with orthoesters: A useful reaction with interesting mechanistic implications. S. Gibson, et al., Tetrahedron Lett. 51, 6737-6740, (2010)

---

2. B. Kocyigit-Kaymakcioglu, et al., Med. Chem. Res. 20, 607-614, (2011)

3. C. C. Cheng, et al., ACS Med. Chem. Lett. 1, 466-471, (2010)

4. Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1. A. Lee-Dutra, et al., Bioorg. Med. Chem. Lett. 20, 2370-2374, (2010)

---

5. Part II: piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation. J. J. Parlow, et al., Bioorg. Med. Chem. Lett. 20, 1388-1394, (2010)

---

6. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). R. Williams, et al., Bioorg. Med. Chem. Lett. 19, 4967-4970, (2009)

---

2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. Patrizia Minetti et al J. Med. Chem. 48, 6887-96, (2005)

---

Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

---

Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4. Andrea Kragler et al Eur. J. Med. Chem. 43, 2404-11, (2008)

---

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Shuang Chang et al Nat. Chem. Biol. 4, 256-63, (2008)

---

N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles. Morteza Malakoutikhah et al J. Med. Chem. 53, 2354-63, (2010)

---

Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)

---

Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. Mark R Faust et al Eur. J. Med. Chem. 45, 2453-66, (2010)

---

Merck 14,6561

Beil. 22,8

Corp MSDS 1 (2), 2545:D / FT-IR 2 (1), 929:C / FT-IR 1 (1), 586:A / FT-NMR 1 (1), 890:A / IR-Spectra (3), 349:B / NMR-Reference 2 (1), 506:A / RegBook 1 (1), 665:I / Sigma FT-IR 1 (2), 774:C / Structure Index 1, 99:B:7