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216143 Aldrich

Tetrabutylammonium fluoride solution

1.0 M in THF

Synonym: TBAF solution



Related Categories Chemical Synthesis, Deprotecting Reagents, Fluoride Sources, Protection and Derivatization, Synthetic Reagents More...
concentration   1.0 M in THF
impurities   ~5 wt. % water
density   0.903 g/mL at 25 °C
storage temp.   2-8°C


Frequently Asked Questions

Frequently Asked Questions are available for this Product.


1 L in Sure/Seal™

5 mL in glass bottle

2.5 L in glass bottle

50, 100, 4×100, 500 mL in Sure/Seal™


Reactant for preparation of:
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Price and Availability

Cross-Coupling Guide
Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
UN 2924 8(3) / PGII
WGK Germany 
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How should Product 216143, Tetrabutylammonium fluoride solution be stored?
This product is hygroscopic and should be stored under inert gas, such as nitrogen, and at 2-8 deg C, which is in accordance with our MSDS.
What applications can 216143 Tetrabutylammonium fluoride solution, be used in?
This product can be used as a fluorinating reagent.  For further information on this application please visit ChemFiles vol. 5 no. 1:   http://www.sigmaaldrich.com/aldrich/brochure/al_chemfile_v5_n1.pdfThis product can also be used as a deprotection reagent.  For further information on this application please see ChemFiles vol. 7 no 3:   http://www.sigmaaldrich.com/aldrich/brochure/al_chemfile_v7_n3.pdf
What causes Product 216143, Tetrabutylammonium fluoride solution, to turn purple?
Our specifications for this product indicate the material should be colorless to yellow in color. Contact with ketones will immediate discoloration sometimes appearing purple in color. 
How can Product 216143, Tetrabutylammonium fluoride solution, be removed from a Sure/Seal™ bottle?
For instructions on how to use the Sure/Seal™ bottles, please click on the below link and select Technical Bulletin AL-134:  http://www.sigmaaldrich.com/Brands/Aldrich/Tech_Bulletins.html
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles


Introduction of Terminal Azide and Alkyne Functionalities in Polymers

“Click” chemistry, and the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in particular, is a powerful new synthetic tool in polymer chemistry and material science. Success of the CuAAC in th...
Dr. Joost A. Opsteen
Material Matters 2008, 3.3, 66.
Keywords: Building blocks, Catalysis, Cycloadditions, Esterifications, Materials Science, Nucleophilic substitutions, Polymer science, Polymerization reactions, Radical polymerization, Substitutions, transformation

Peer-Reviewed Papers


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