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219819 Aldrich

2-Hydroxyisocaproic acid


Synonym: 2-Hydroxy-4-methylvaleric acid, DL-leucic acid



Related Categories Building Blocks, C6, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
assay   99%
mp   78-80 °C(lit.)



1 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 219819.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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WGK Germany 

Protocols & Articles

Peer-Reviewed Papers


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Extraction-spectrophotometric determination of antimony (V) with 2-hydroxyisocaproic acid and citrate, with application to differential determination of antimony (V) and antimony (III). SATO S and UCHIKAWA S. Anal. Sci. 2, 47, (1986)

2-Hydroxyisocaproic acid (HICA): a new potential topical antibacterial agent. Sakko M, Tjäderhane L, Sorsa T, et al. Int. J. Antimicrob. Agents 39(6), 539-40, (2012)


Severe illness caused by the products of bacterial metabolism in a child with a short gut. Haan E, Brown G, Bankier A, et al. Eur. J. Pediatr. 144(1), 63-5, (1985)


Alpha-keto acids are novel siderophores in the genera Proteus, Providencia, and Morganella and are produced by amino acid deaminases. Drechsel H, Thieken A, Reissbrodt R, et al. J. Bacteriol. 175(9), 2727-33, (1993)


Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. Jakobs C, Sweetman L, and Nyhan WL Clin. Chim. Acta 140(2), 157-66, (1984)


Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats. Boebel KP and Baker DH J. Nutr. 112(10), 1929-39, (1982)


Urinary D-4-hydroxyphenyllactate, D-phenyllactate and D-2-hydroxyisocaproate, abnormalities of bacterial origin. Spaapen LJ, Ketting D, Wadman SK, et al. J. Inherit. Metab. Dis. 10(4), 383-90, (1987)


Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. Kuhara T, Shinka T, Inoue Y, et al. Clin. Chim. Acta 133(2), 133-40, (1983)


Bioactivation mechanism of L-thiomorpholine-3-carboxylic acid. Webster KD and Anders MW Arch. Biochem. Biophys. 273(2), 562-71, (1989)


[The growth of rats in renal compensatory adaptation in feeding with a supplemented diet of hydroxy-analogs of essential amino acids]. Friedrich M, Wüstenberg PW, Hinz U, et al. Z. Urol. Nephrol. 82(2), 105-12, (1989)


Continuous enzymatically catalyzed production of L-leucine from the corresponding racemic hydroxy acid. Bossow B and Wandrey C Ann. N. Y. Acad. Sci. 506, 325-36, (1987)


Polymer, Assisted Solution Phase Synthesis of tr, Ketoamides. Parlow JJ, et al. High-Throughput Synthesis: Principles and Practices, (2001), 143

Beil. 3,336

Aldrich MSDS 1, 1061:C / Corp MSDS 1 (1), 1928:D / FT-IR 1 (1), 519:A / FT-IR 2 (1), 807:C / FT-NMR 1 (1), 809:B / IR-Spectra (3), 304:A / NMR-Reference 2 (1), 455:B / RegBook 1 (1), 565:O / Sigma FT-IR 1 (1), 1403:A / Structure Index 1, 81:B:1

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