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219819 Aldrich

2-Hydroxyisocaproic acid


Synonym: 2-Hydroxy-4-methylvaleric acid, DL-leucic acid



Related Categories Building Blocks, C6, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
assay   99%
mp   78-80 °C(lit.)



1 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 219819.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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WGK Germany 
Protocols & Articles
Peer-Reviewed Papers


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Extraction-spectrophotometric determination of antimony (V) with 2-hydroxyisocaproic acid and citrate, with application to differential determination of antimony (V) and antimony (III). SATO S and UCHIKAWA S. Anal. Sci. 2, 47, (1986)

Lipidomic profiling reveals significant alterations in lipid biochemistry in hypothyroid rat cerebellum and the therapeutic effects of Sini decoction. Wu S, Chen S, Dong X, et al. J. Ethnopharmacol. 159, 262-73, (2014)


Severe illness caused by the products of bacterial metabolism in a child with a short gut. Haan E, Brown G, Bankier A, et al. Eur. J. Pediatr. 144(1), 63-5, (1985)


Urinary D-4-hydroxyphenyllactate, D-phenyllactate and D-2-hydroxyisocaproate, abnormalities of bacterial origin. Spaapen LJ, Ketting D, Wadman SK, et al. J. Inherit. Metab. Dis. 10(4), 383-90, (1987)


Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. Jakobs C, Sweetman L, and Nyhan WL Clin. Chim. Acta 140(2), 157-66, (1984)


Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats. Boebel KP and Baker DH J. Nutr. 112(10), 1929-39, (1982)


Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. Kuhara T, Shinka T, Inoue Y, et al. Clin. Chim. Acta 133(2), 133-40, (1983)


Alpha-keto acids are novel siderophores in the genera Proteus, Providencia, and Morganella and are produced by amino acid deaminases. Drechsel H, Thieken A, Reissbrodt R, et al. J. Bacteriol. 175(9), 2727-33, (1993)


[The growth of rats in renal compensatory adaptation in feeding with a supplemented diet of hydroxy-analogs of essential amino acids]. Friedrich M, Wüstenberg PW, Hinz U, et al. Z. Urol. Nephrol. 82(2), 105-12, (1989)


Continuous enzymatically catalyzed production of L-leucine from the corresponding racemic hydroxy acid. Bossow B and Wandrey C Ann. N. Y. Acad. Sci. 506, 325-36, (1987)


Bioactivation mechanism of L-thiomorpholine-3-carboxylic acid. Webster KD and Anders MW Arch. Biochem. Biophys. 273(2), 562-71, (1989)


2-Hydroxyisocaproic acid (HICA): a new potential topical antibacterial agent. Sakko M, Tjäderhane L, Sorsa T, et al. Int. J. Antimicrob. Agents 39(6), 539-40, (2012)


Polymer, Assisted Solution Phase Synthesis of tr, Ketoamides. Parlow JJ, et al. High-Throughput Synthesis: Principles and Practices, (2001), 143

Beil. 3,336

Aldrich MSDS 1, 1061:C / Corp MSDS 1 (1), 1928:D / FT-IR 1 (1), 519:A / FT-IR 2 (1), 807:C / FT-NMR 1 (1), 809:B / IR-Spectra (3), 304:A / NMR-Reference 2 (1), 455:B / RegBook 1 (1), 565:O / Sigma FT-IR 1 (1), 1403:A / Structure Index 1, 81:B:1

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