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22600 Aldrich

Quinidine

crystallized, ≥98.0% (dried material, NT)

  • CAS Number 56-54-2

  • Empirical Formula (Hill Notation) C20H24N2O2

  • Molecular Weight 324.42

  •  Beilstein Registry Number 91866

  •  EC Number 200-279-0

  •  MDL number MFCD00135581

  •  PubChem Substance ID 57647992

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Properties

Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Chiral Resolution Reagents, Chiral Resolving Reagents,
InChI Key   LOUPRKONTZGTKE-LHHVKLHASA-N
assay   ≥98.0% (dried material, NT)
optical activity   [α]20/D +265±5°, c = 0.8% in ethanol (dry matter)
quality   crystallized
impurities   ≤2% water
  ~10% hydroquinidine (HPLC)
mp   168-172 °C(lit.)
Gene Information   human ... ABCB1(5243), CYP2D6(1565), CYP3A4(1576), KCNH1(3756)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

Description

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

Other Notes

Chiral catalyst, used e.g. in highly enantioselective [2+2] cycloadditions

Packaging

10, 50 g in poly bottle

Application

Quinidine may be used in the preparation of O-trimethylsilylquinidine by reacting trimethylsilyl chloride.

General description

Quinidine is an isomer of quinine.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
VA4725000
Protocols & Articles

Articles

Cinchona Alkaloids - Aldrich ChemFiles 2008, 8.2, 74.

Cinchona alkaloids and their derivatives have proven to catalyze an astonishing array of enantioselective transformations, providing access to chiral products of high enantiopurity.1 The presence of ...
William Sommer and Daniel Weibel
Aldrich ChemFiles 2008, 8.2, 74.
Keywords: Addition reactions, Aminations, Antimicrobials, Asymmetric synthesis, Catalysis, Desymmetrizations, Dihydroxylations, Ligands, Reductive aminations

HPLC Analysis of Alkaloids on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Alkaloids on Discovery® RP-AmideC16
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Alkaloids on Discovery® Zr-PBD

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Alkaloids on Discovery® Zr-PBD
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Amides on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Amides on Discovery® RP-Amide C16
Keywords: Analgesics, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Basic Drug Panel on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Basic Drug Panel on Ascentis® Express C18
Keywords: Anti-depressants, Antihypertensives, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Hydrophobic Bases on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hydrophobic Bases on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Quinidine and Trace Impurity on Discovery® HS F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Quinidine and Trace Impurity on Discovery® HS F5
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Higher Efficiency of Ascentis® Express 2.7 μm Compared to 3 μm Particles Gives Better Sensitivity

From our library of Articles, Sigma-Aldrich presents Higher Efficiency of Ascentis® Express 2.7 μm Compared to 3 μm Particles Gives Better Sensitivity
Keywords: Anti-depressants, Chromatography, High performance liquid chromatography, Pharmaceutical

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18
Keywords: Antihypertensives, Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Precipitation, Solid phase extractions

UHPLC Analysis of Quinidine and Metabolite on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Quinidine and Metabolite on Titan™ C18
Keywords: Chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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