Synonym: Propargylacetic acid
|Related Categories||Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,|
|bp||110 °C/30 mmHg(lit.)|
1, 5 g in glass bottle
Reaction with 1-bromo-1-alkynes in the presence of a Pd catalyst yields biologically active ynenol lactones.1
Used in a synthesis of a cyctotoxic macrolide by ring-closing metathesis of a bis acetylene.
Certificate of Analysis
|Precautionary statements||P280-P305 + P351 + P338-P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||C|
|Risk Statements (Europe)||34|
|Safety Statements (Europe)||26-36/37/39-45|
|RIDADR||UN 3261 8 / PGII|
“Click” chemistry, and the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in particular, is a powerful new synthetic tool in polymer chemistry and material science. Success of the CuAAC in th...
Dr. Joost A. Opsteen
Material Matters 2008, 3.3, 66.
Keywords: Building blocks, Catalysis, Cycloadditions, Esterifications, Materials Science, Nucleophilic substitutions, Polymer science, Polymerization reactions, Radical polymerization, Substitutions, transformation
Aldrich Chemistry lists over 600 alkyne building blocks, including a wide array of propargyl alcohols, acetylenic boron reagents, and halogenated substrates for cross-coupling. Additionally, many of ...
Keywords: Building blocks, Coupling reactions, Cross couplings
1. Tetrahedron Lett. 33, 2811, (1992)
5-[4-(3,3-Dimethylbutoxycarbonyl)phenyl]-4-pentynoic acid and its derivatives inhibit ionotropic gamma-aminobutyric acid receptors by binding to the 4'-ethynyl-4-n-propylbicycloorthobenzoate site. Hamano H, Nagata K, Fukada TN, et al. Bioorg. Med. Chem. 8(3), 665-74, (2000)
Aldrich MSDS 1, 1443:C / Corp MSDS 1 (2), 2724:B / FT-IR 1 (2), 943:C / FT-IR 2 (3), 4038:C / FT-NMR 1 (3), 525:C / NMR-Reference 2 (2), 959:D / RegBook 1 (2), 2707:L / Structure Index 1, 426:D:9 / Vapor Phase 3, 1595:C
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?