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232211 Aldrich

4-Pentynoic acid

95%

Synonym: Propargylacetic acid

Properties

Related Categories Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis,
assay   95%
bp   110 °C/30 mmHg(lit.)
mp   54-57 °C(lit.)
storage temp.   2-8°C

Description

Packaging

1, 5 g in glass bottle

Application

4-Pentynoic acid was used:
• as building block for the synthesis of library of eight sequence-defined model oligomers1
• in one-pot synthesis of the complex polycyclic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivatives2
• in the synthesis of various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furanones]3
• in the synthesis of a cyctotoxic macrolide by ring-closing metathesis of a bis acetylene4

General description

4-Pentynoic acid undergoes copper-catalyzed intramolecular cyclizations to form enol lactones5. It also reacts with 1-bromo-1-alkynes in the presence of a Pd catalyst to yield biologically active ynenol lactones6.

Price and Availability

Suggested Laboratory Gloves


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