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234478 Aldrich

1-Chloro-3-iodopropane

99%

Synonym: Trimethylene chloroiodide

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Properties

Related Categories Alkyl, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, Organic Building Blocks More...
vapor density   6.8 (vs air)
vapor pressure   2 mmHg ( 20 °C)
InChI Key   SFOYQZYQTQDRIY-UHFFFAOYSA-N
assay   99%
contains   copper as stabilizer
refractive index   n20/D 1.548(lit.)
bp   170-172 °C(lit.)
density   1.904 g/mL at 25 °C(lit.)

Description

Packaging

25, 100 g in glass bottle

Application

1-Chloro-3-iodopropane has been used in the synthesis of:
• N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase)
• interesting ″proton sponge″ type molecule quino[7,8-h]quinoline

General description

1-Chloro-3-iodopropane undergoes asymmetric α-alkylation with N-sulfinyl imidates to yield 2-substituted N-tert-butanesulfinyl-5-chloropentanimidates. Electroreduction of 1-chloro-3-iodopropane at glassy carbon electrode in dimethylformamide containing tetra-n-butylammonium perchlorate has been investigated by cyclic voltammetry. It also participates in conjugate addition of alkyl iodides to α,β-unsaturated nitriles in water.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
230 °F
Flash Point(C) 
110 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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