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235695 Aldrich

Octamethylcyclotetrasiloxane

98%

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Properties

Related Categories Chemical Synthesis, Materials Science, Micro/NanoElectronics, Organometallic Reagents, Organosilicon,
vapor density   1 (vs air)
assay   98%
form   liquid
refractive index   n20/D 1.396(lit.)
bp   175-176 °C(lit.)
mp   17-18 °C(lit.)
density   0.956 g/mL at 25 °C(lit.)

Description

Packaging

25, 100 g in glass bottle

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
36/37-46-51-61
RIDADR 
UN 1993C 3 / PGIII
WGK Germany 
3
RTECS 
GZ4397000
Flash Point(F) 
131 °F
Flash Point(C) 
55 °C

Protocols & Articles

Articles

Determination of Water Content in Octamethylcyclotetrasiloxane Using Karl Fischer Titration

Determining the water content can be carried out volumetrically in methanol without any problems. As the water content of the sample is only 40 ppm, however, the coulometric method is also an obvious...
Keywords: Esterifications, Titrations

Low κ Precursors

Low κ materials address technical challenges of increased chip performance by allowing for the reduction of spacing between metals in multi-level interconnects, interlayer dielectrics and passivation...
Chemfiles Volume 4 Article 3
Keywords: Atomic layer deposition, Chemical vapor deposition, Chromatin immunoprecipitation, Reductions

Peer-Reviewed Papers

References

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Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs). Hanssen L, Warner NA, Braathen T, et al. Environ. Int. 51, 82-7, (2013)

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Physiologically based pharmacokinetic modeling of the disposition of octamethylcyclotetrasiloxane (D4) migration from implants in humans. Thrall KD, Soelberg JJ, Powell T, et al. J. Long. Term. Eff. Med. Implants 18(2), 133-44, (2008)

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[Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa]. Zhen HS, Ge J, Liang J, et al. Zhong Yao Cai 31(5), 677-8, (2008)

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Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure. Wang R, Moody RP, Koniecki D, et al. Environ. Int. 35(6), 900-4, (2009)

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Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China. Xu L, Shi Y, and Cai Y Water Res. 47(2), 715-24, (2013)

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In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes. Quinn AL, Regan JM, Tobin JM, et al. Toxicol. Sci. 96(1), 145-53, (2007)

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Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise. Reddy MB, Andersen ME, Morrow PE, et al. Toxicol. Sci. 72(1), 3-18, (2003)

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Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha. He B, Rhodes-Brower S, Miller MR, et al. Toxicol. Appl. Pharmacol. 192(3), 254-61, (2003)

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Allometric relationships to liver tissue concentrations of cyclic volatile methyl siloxanes in Atlantic cod. Warner NA, Nøst TH, Andrade H, et al. Environ. Pollut. 190, 109-14, (2014)

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Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)). Reddy MB, Looney RJ, Utell MJ, et al. Toxicol. Sci. 99(2), 422-31, (2007)

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Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model. Zareba G, Gelein R, Morrow PE, et al. Skin Pharmacol. Appl. Skin Physiol. 15(3), 184-94, (2002)

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Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane. Sarangapani R, Teeguarden J, Plotzke KP, et al. Toxicol. Sci. 67(2), 159-72, (2002)

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A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation. Siddiqui WH, Stump DG, Plotzke KP, et al. Reprod. Toxicol. 23(2), 202-15, (2007)

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Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models. Sarangapani R, Teeguarden J, Andersen ME, et al. Toxicol. Sci. 71(1), 41-52, (2003)

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In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5). Jovanovic ML, McMahon JM, McNett DA, et al. Regul Toxicol Pharmacol 50(2), 239-48, (2008)

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Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans. Reddy MB, Dobrev ID, McNett DA, et al. Toxicol. Sci. 105(2), 275-85, (2008)

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Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures? Andersen ME, Reddy MB, and Plotzke KP Toxicol. Lett. 179(2), 85-92, (2008)

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An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens. Meeks RG, Stump DG, Siddiqui WH, et al. Reprod. Toxicol. 23(2), 192-201, (2007)

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Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats. Quinn AL, Dalu A, Meeker LS, et al. Reprod. Toxicol. 23(4), 532-40, (2007)

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Effect of ozone and relative humidity on the heterogeneous uptake of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane on model mineral dust aerosol components. Navea JG, Xu S, Stanier CO, et al. J. Phys. Chem. A 113(25), 7030-8, (2009)

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PBPK modeling advances understanding of D4 pharmacokinetics. Fisher JW Toxicol. Sci. 72(1), 1-2, (2003)

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Effect of octamethylcyclotetrasiloxane on methylation of bismuth by Methanosarcina barkeri. Michalke K, Meyer J, and Hensel R Appl. Environ. Microbiol. 72(10), 6819-21, (2006)

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Siloxane treatment by adsorption into porous materials. Ricaurte Ortega D and Subrenat A Environ. Technol. 30(10), 1073-83, (2009)

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Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies. Dobrev ID, Nong A, Liao KH, et al. Inhal. Toxicol. 20(4), 361-73, (2008)

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Further comments on the bioavailability of D4. Andersen ME, Dobrev ID, Reddy MB, et al. Environ. Health Perspect. 110(8), A444-5; author reply A445-8, (2002)

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Bioavailability of D4 after inhalation and implantation exposure to silicones. Meeks RG Environ. Health Perspect. 110(8), A442-3; author reply A445-8, (2002)

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Merck 14,6747

Beil. 4,IV,4125

Aldrich MSDS 1, 1400:D / Corp MSDS 1 (2), 2639:A / FT-IR 1 (2), 1102:A / FT-IR 2 (3), 4388:A / NMR-Reference 2 (2), 989:C / RegBook 1 (2), 2977:D / Structure Index 1, 471:D:5 / Vapor Phase 3, 1651:B

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