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23955 Aldrich

Chlorodipyrrolidinocarbenium hexafluorophosphate

≥98.0% (CHN)

Synonym: N,N,N′,N′-Bis(tetramethylene)chloroformamidinium hexafluorophosphate, Chloro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate, PyClU

  • CAS Number 135540-11-3

  • Linear Formula C9H16N2Cl · PF6

  • Molecular Weight 332.65

  •  Beilstein Registry Number 7898575

  •  MDL number MFCD00191333

  •  PubChem Substance ID 24854379

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling,
InChI Key   NHEGCUSBUWGOQM-UHFFFAOYSA-N
assay   ≥98.0% (CHN)
mp   153-156 °C
storage temp.   2-8°C

Description

Other Notes

Crystalline and non-hygroscopic peptide coupling reagent, especially for N-methyl amino acids

Packaging

5 g in glass bottle

Application

Reactant for:
Enantioselective desymmetrization of meso-asiridines
Peptide coupling
Reagent for:
Heterocyclization of chloroformamidinium salts
Oxidative insertion for palladium and nickel catalyst synthesis

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Acid Halogenation Reagents

The generation of an acid chloride is an obvious way to activate the carboxy group for amide bond formation. However, practical application of acid chlorides in peptide synthesis is restricted, becau...
Matthias Junkers
Aldrich ChemFiles 2007, 7.2, 3.
Keywords: Chemfiles, Fluorinations, Halogenations, Peptide synthesis, Racemizations, Solid phase peptide synthesis

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COMU – Safer and More Efficient Peptide Coupling Reagent

Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Catalog, Condensations, Coupling reactions, Epimerizations, Methods, PEGylations, Peptide synthesis, Protocols, Racemizations, Search, Solid phase peptide synthesis, Solvents, Tools

Peer-Reviewed Papers
15

References

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