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242926 Aldrich

Dimethyl fumarate

97%

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Properties

Related Categories Building Blocks, C6 to C7, Carbonyl Compounds, Chemical Synthesis, Esters,
assay   97%
bp   192-193 °C(lit.)
mp   102-106 °C(lit.)

Description

Packaging

25, 100 g in glass bottle

Application

Dimethyl fumarate was used in the preparation of an adduct [dimethyl-(+)-(11R,12R)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylate] with anthracene1.

Price and Availability

Suggested Laboratory Gloves


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Dimethyl fumarate

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98 atom % D, 98% (CP)

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36/37
WGK Germany 
1
RTECS 
EM6125000

Protocols & Articles

Peer-Reviewed Papers

References

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1. Importance of C*-H Based Modes and Large Amplitude Motions Effects in Vibrational Circular Dichroism Spectra: The Case of the Chiral Adduct of Dimethyl Fumarate and Anthracene. Passarello M, Abbate S, Longhi G, et al. J. Phys. Chem. A, (2014)

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Dimethyl fumarate for multiple sclerosis. Papadopoulou A, D'Souza M, Kappos L, et al. Expert Opin. Investig. Drugs 19(12), 1603-12, (2010)

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[Immunomodulation with oral dosage forms and their mechanisms of action]. Gold R Drug Res. (Stuttg.) 63 Suppl 1, S9, (2013)

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Dimethyl fumarate (BG-12) for the treatment of multiple sclerosis. Stangel M and Linker RA Expert Rev. Clin. Pharmacol. 6(4), 355-62, (2013)

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Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts. Van Ly D J. Allergy (Cairo.) 2011, 457169, (2011)

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Chemistry of Ru(eta6-1,3,5-cyclooctatriene)(eta2-dimethyl fumarate)2. Mitsudo TA, Ura Y, and Kondo T Chem. Rec. 6(3), 107-16, (2006)

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Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy. Gill AJ and Kolson DL Crit. Rev. Immunol. 33(4), 307-59, (2013)

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Dimethyl fumarate - only an anti-psoriatic medication? Meissner M, Valesky EM, Kippenberger S, et al. J. Dtsch. Dermatol. Ges. 10(11), 793-801, (2012)

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Dimethyl fumarate for treatment of multiple sclerosis: mechanism of action, effectiveness, and side effects. Linker RA and Gold R Curr. Neurol. Neurosci. Rep. 13(11), 394, (2013)

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Dimethyl fumarate regulates histone deacetylase expression in astrocytes. Kalinin S, Polak PE, Lin SX, et al. J. Neuroimmunol. 263(1-2), 13-9, (2013)

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Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. Chen H, Assmann JC, Krenz A, et al. J. Clin. Invest. 124(5), 2188-92, (2014)

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Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs. Tsubaki M, Komai M, Itoh T, et al. Eur. J. Cancer 49(17), 3708-17, (2013)

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Dimethyl fumarate : a Janus-faced substance? Kees F Expert Opin. Pharmacother. 14(11), 1559-67, (2013)

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Effects of fumaric acid esters on blood-brain barrier tight junction proteins. Bénardais K, Pul R, Singh V, et al. Neurosci. Lett. 555, 165-70, (2013)

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Successful treatment of discoid lupus erythematosus with fumaric acid esters. Tsianakas A, Herzog S, Landmann A, et al. J. Am. Acad. Dermatol. 71(1), e15-7, (2014)

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Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation. Reick C, Ellrichmann G, Thöne J, et al. Exp. Neurol. 257, 50-6, (2014)

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Beil. 2,IV,2205

Aldrich MSDS 1, 772:A / Corp MSDS 1 (1), 1376:D / FT-IR 2 (1), 1039:D / FT-IR 1 (1), 644:D / FT-NMR 1 (1), 993:B / NMR-Reference 2 (1), 543:D / RegBook 1 (1), 725:L / Sax 6, 1164 / Structure Index 1, 111:D:2 / Vapor Phase 3, 689:C

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