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MilliporeSigma

254886

6,7-Dimethoxycoumarin

98%

Synonym(s):

6,7-Dimethylesculetin, O-Methylisoscopoletin, O-Methylscopoletin, Aesculetin dimethyl ether, Escoparone, Esculetin 6,7-dimethyl ether, Scoparone, Scopoletin methyl ether

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250 MG

$187.00

1 G

$414.00

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About This Item

Empirical Formula (Hill Notation):
C11H10O4
CAS Number:
120-08-1
Molecular Weight:
206.19
EC Number:
204-369-0
MDL number:
MFCD00006871
UNSPSC Code:
12352100
PubChem Substance ID:
24855271
NACRES:
NA.22

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Quality Level

200

assay

98%

form

powder

mp

143-145 °C (lit.)

functional group

ester

SMILES string

COc1cc2OC(=O)C=Cc2cc1OC

InChI

1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

Inchi Key

GUAFOGOEJLSQBT-UHFFFAOYSA-N

Gene Information

mouse ... Maoa(17161)
rat ... Aldh1a2(116676)

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1 of 4

This Item
E825064951PHL89733
6,7-Dimethoxycoumarin 98%

Sigma-Aldrich

254886

6,7-Dimethoxycoumarin

Esculin hydrate ≥98%

Sigma-Aldrich

E8250

Esculin hydrate

7-Methoxycoumarin suitable for fluorescence, ≥98.0% (TLC)

Sigma-Aldrich

64951

7-Methoxycoumarin

7-Methoxycoumarin phyproof® Reference Substance

PHL89733

7-Methoxycoumarin

assay

98%

assay

≥98%

assay

≥98.0% (TLC)

assay

≥98.0% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

form

powder

form

-

form

solid

form

crystals

mp

143-145 °C (lit.)

mp

-

mp

117-121 °C (lit.)

mp

117-121 °C (lit.)

functional group

ester

functional group

-

functional group

-

functional group

-

Gene Information

mouse ... Maoa(17161)
rat ... Aldh1a2(116676)

Gene Information

-

Gene Information

-

Gene Information

-

General description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea[1]. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported[2].

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBL2777
STBK2159
STBH2509
STBH5675
STBH4841

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Chung-Ping Yu et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 101, 66-70 (2017-02-12)
Chronic kidney disease (CKD) is a health problem worldwide. Indoxyl sulfate (IS) is a nephro-cardiovascular toxin accumulated in CKD patients and cannot be removed through hemodialysis. The renal excretion of IS was mediated by organic anion transporters (OATs) OAT 1
Xijun Wang et al.
Rapid communications in mass spectrometry : RCM, 21(23), 3883-3890 (2007-11-06)
Scoparone (6,7-dimethoxycoumarin) is known to have a wide range of pharmacological properties. In this study, a rapid and validated ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-QTof-MS) method was developed to investigate the metabolism of scoparone in rat for
Kai He et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 881-882, 49-54 (2011-12-27)
It is known that the choice of solvent system for high speed counter-current chromatography separation is of utmost importance. In this study, a simple and rapid thin layer chromatograph coupling with fluorometric (TLC-F) method has been used to determine the
Aihua Zhang et al.
Biomedical chromatography : BMC, 26(7), 844-850 (2011-11-10)
Increasing evidence has demonstrated that multidrug combinations could amplify the therapeutic efficacies of each agent. Interestingly, the pharmacological effect of traditional Chinese medicine (TCM) is usually attributed to the drug-interaction property (synergism) of multiple active constituents. Pharmacokinetics is a useful
Dongfang Yang et al.
British journal of pharmacology, 164(5), 1547-1557 (2011-06-09)
Hyperbilirubinaemia and cholestasis are two major forms of liver abnormality. The Chinese herb Yin Chin has been used for thousands of years to treat liver dysfunctions. In mice, this herb and its principal ingredient scoparone were found to accelerate the
View All Related Papers

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