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254886 Aldrich

6,7-Dimethoxycoumarin

98%

Synonym: Scoparone

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Description

Packaging

1 g in glass bottle

250 mg in glass bottle

General description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea1. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported2.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
GN6550000

Protocols & Articles

Peer-Reviewed Papers

References

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1. 6, 7-Dimethoxycoumarin, a citrus phytoalexin conferring resistance against Phytophthora gummosis. Afek U, et al. Phytochemistry 25(8), 1855-56, (1986)

2. Determination and pharmacokinetics of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of yinchenhao tang. Yu ZG, Wang Q, Li K, et al. J. Chromatogr. Sci. 45(8), 544-8, (2007)

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[Study on distributed patterns of scoparone and ayapin in Dendrobium species from Yunnan]. Liu YY, Yu H, Yuan F, et al. Zhongguo Zhong Yao Za Zhi 38(21), 3691-5, (2013)

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[A new natural product from root of Angelica dahurica cv. Qibaizhi]. Zhao A, Yang X, Yang X, et al. Zhongguo Zhong Yao Za Zhi 37(16), 2400-7, (2012)

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[Studies on the chemical constituents from Lobelia chinensis]. Chen JX, Huang SH, Wang Y, et al. Zhong Yao Cai 33(11), 1721-4, (2010)

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[Main chemical components for clearing heat and relieving sore throat in different germplasm of Canarium album]. Wang H, Song L, Tang H, et al. Zhongguo Zhong Yao Za Zhi 35(6), 669-72, (2010)

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Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats. Murat Bilgin H, Atmaca M, et al. Exp. Toxicol. Pathol. 63, 325-330, (2011)

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[Isolation and identification of chemical constituents from peels of Citrus changshan-huyou Y.B. Chang]. Zhao XM, Ye XQ, and Zhu da Y Beijing Da Xue Xue Bao. 41(5), 575-7, (2009)

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[Studies on chemical constituents of Ranunculus japonicus]. Liang YF, Chen ZT, and Liu LH Zhongguo Zhong Yao Za Zhi 33(19), 2201-3, (2008)

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Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice. Noh JR, Gang GT, Kim YH, et al. Food Chem. Toxicol. 48(11), 3177-83, (2010)

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Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor. Yang D, Yang J, Shi D, et al. Br. J. Pharmacol. 164(5), 1547-57, (2011)

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Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Noh JR, Kim YH, Gang GT, et al. Food Chem. Toxicol. 49(7), 1537-43, (2011)

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The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats. Atmaca M, Bilgin HM, Obay BD, et al. J. Physiol. Biochem. 67(4), 569-76, (2011)

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Pharmacokinetics and tissue distribution study of scoparone in rats by ultraperformance liquid-chromatography with tandem high-definition mass spectrometry. Yin Q, Sun H, Zhang A, et al. Fitoterapia 83(4), 795-800, (2012)

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Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples. Zhang A, Sun H, Wang X, et al. Biomed. Chromatogr. 26(7), 844-50, (2012)

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Anti-allergic effects of scoparone on mast cell-mediated allergy model. Choi YH and Yan GH Phytomedicine 16(12), 1089-94, (2009)

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Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes. Noh JR, Kim YH, Hwang JH, et al. Food Chem. 141(2), 723-30, (2013)

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Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities. Kuo PC, Hwang TL, Lin YT, et al. Arch. Pharm. Res. 34(5), 715-22, (2011)

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Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Vila-Nova NS, de Morais SM, Falcão MJ, et al. Exp. Parasitol. 133(3), 334-8, (2013)

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Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation. Lv H, Sun H, Wang X, et al. J. Sep. Sci. 31(4), 659-66, (2008)

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Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography. He K, Ye X, Li X, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 881-882, 49-54, (2012)

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Development of a rapid and validated method for investigating the metabolism of scoparone in rat using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Wang X, Lv H, Sun H, et al. Rapid Commun. Mass Spectrom. 21(23), 3883-90, (2007)

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Effect of scoparone on neurite outgrowth in PC12 cells. Yang YJ, Lee HJ, Choi DH, et al. Neurosci. Lett. 440(1), 14-8, (2008)

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Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Yang YJ, Lee HJ, Huang HS, et al. J. Neurosci. Res. 87(8), 1929-37, (2009)

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A simple RP-HPLC method for quantification of columbianadin in rat plasma and its application to pharmacokinetic study. Zhang YB and Yang XW Biomed. Chromatogr. 24(4), 433-7, (2010)

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Effects of scoparone on dopamine release in PC12 cells. Yang YJ, Lee HJ, Lee BK, et al. Fitoterapia 81(6), 497-502, (2010)

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Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment. Lv JL, Li RS, Jin SY, et al. Chin. J. Integr. Med. 18(11), 831-6, (2012)

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Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application to pharmacokinetic studies of Yin Chen Hao Tang preparation. Wang X, Lv H, Sun H, et al. Arzneimittelforschung 58(7), 336-41, (2008)

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7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro. Kielbus M, Skalicka-Wozniak K, Grabarska A, et al. Anticancer Res. 33(10), 4347-56, (2013)

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Merck 14,8404

Beil. 18,99

Corp MSDS 1 (1), 1314:D / FT-IR 2 (2), 2909:B / FT-IR 1 (2), 324:A / RegBook 1 (2), 1943:K / Sax 6, 1158 / Structure Index 1, 312:A:8

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