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254886 Aldrich

6,7-Dimethoxycoumarin

98%

Synonym: Scoparone

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Description

Packaging

1 g in glass bottle

250 mg in glass bottle

General description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea1. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported2.

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
26
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
GN6550000

Protocols & Articles

Peer-Reviewed Papers

References

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1. 6, 7-Dimethoxycoumarin, a citrus phytoalexin conferring resistance against Phytophthora gummosis. Afek U, et al. Phytochemistry 25(8), 1855-56, (1986)

2. Determination and pharmacokinetics of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of yinchenhao tang. Yu ZG, Wang Q, Li K, et al. J. Chromatogr. Sci. 45(8), 544-8, (2007)

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[Study on distributed patterns of scoparone and ayapin in Dendrobium species from Yunnan]. Liu YY, Yu H, Yuan F, et al. Zhongguo Zhong Yao Za Zhi 38(21), 3691-5, (2013)

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[A new natural product from root of Angelica dahurica cv. Qibaizhi]. Zhao A, Yang X, Yang X, et al. Zhongguo Zhong Yao Za Zhi 37(16), 2400-7, (2012)

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[Studies on the chemical constituents from Lobelia chinensis]. Chen JX, Huang SH, Wang Y, et al. Zhong Yao Cai 33(11), 1721-4, (2010)

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[Main chemical components for clearing heat and relieving sore throat in different germplasm of Canarium album]. Wang H, Song L, Tang H, et al. Zhongguo Zhong Yao Za Zhi 35(6), 669-72, (2010)

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Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats. Murat Bilgin H, Atmaca M, et al. Exp. Toxicol. Pathol. 63, 325-330, (2011)

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[Isolation and identification of chemical constituents from peels of Citrus changshan-huyou Y.B. Chang]. Zhao XM, Ye XQ, and Zhu da Y Beijing Da Xue Xue Bao. 41(5), 575-7, (2009)

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[Studies on chemical constituents of Ranunculus japonicus]. Liang YF, Chen ZT, and Liu LH Zhongguo Zhong Yao Za Zhi 33(19), 2201-3, (2008)

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Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice. Noh JR, Gang GT, Kim YH, et al. Food Chem. Toxicol. 48(11), 3177-83, (2010)

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Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor. Yang D, Yang J, Shi D, et al. Br. J. Pharmacol. 164(5), 1547-57, (2011)

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Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Noh JR, Kim YH, Gang GT, et al. Food Chem. Toxicol. 49(7), 1537-43, (2011)

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The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats. Atmaca M, Bilgin HM, Obay BD, et al. J. Physiol. Biochem. 67(4), 569-76, (2011)

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Pharmacokinetics and tissue distribution study of scoparone in rats by ultraperformance liquid-chromatography with tandem high-definition mass spectrometry. Yin Q, Sun H, Zhang A, et al. Fitoterapia 83(4), 795-800, (2012)

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Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples. Zhang A, Sun H, Wang X, et al. Biomed. Chromatogr. 26(7), 844-50, (2012)

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Anti-allergic effects of scoparone on mast cell-mediated allergy model. Choi YH and Yan GH Phytomedicine 16(12), 1089-94, (2009)

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Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes. Noh JR, Kim YH, Hwang JH, et al. Food Chem. 141(2), 723-30, (2013)

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Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities. Kuo PC, Hwang TL, Lin YT, et al. Arch. Pharm. Res. 34(5), 715-22, (2011)

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Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Vila-Nova NS, de Morais SM, Falcão MJ, et al. Exp. Parasitol. 133(3), 334-8, (2013)

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Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation. Lv H, Sun H, Wang X, et al. J. Sep. Sci. 31(4), 659-66, (2008)

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Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography. He K, Ye X, Li X, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 881-882, 49-54, (2012)

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Development of a rapid and validated method for investigating the metabolism of scoparone in rat using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Wang X, Lv H, Sun H, et al. Rapid Commun. Mass Spectrom. 21(23), 3883-90, (2007)

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Effect of scoparone on neurite outgrowth in PC12 cells. Yang YJ, Lee HJ, Choi DH, et al. Neurosci. Lett. 440(1), 14-8, (2008)

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Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Yang YJ, Lee HJ, Huang HS, et al. J. Neurosci. Res. 87(8), 1929-37, (2009)

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A simple RP-HPLC method for quantification of columbianadin in rat plasma and its application to pharmacokinetic study. Zhang YB and Yang XW Biomed. Chromatogr. 24(4), 433-7, (2010)

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Effects of scoparone on dopamine release in PC12 cells. Yang YJ, Lee HJ, Lee BK, et al. Fitoterapia 81(6), 497-502, (2010)

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Changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate-induced experimental hepatic injury after Yinchenhao Decoction () treatment. Lv JL, Li RS, Jin SY, et al. Chin. J. Integr. Med. 18(11), 831-6, (2012)

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Simultaneous determination of 6,7-dimethylesculetin and geniposide in rat plasma and its application to pharmacokinetic studies of Yin Chen Hao Tang preparation. Wang X, Lv H, Sun H, et al. Arzneimittelforschung 58(7), 336-41, (2008)

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7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro. Kielbus M, Skalicka-Wozniak K, Grabarska A, et al. Anticancer Res. 33(10), 4347-56, (2013)

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Merck 14,8404

Beil. 18,99

Corp MSDS 1 (1), 1314:D / FT-IR 2 (2), 2909:B / FT-IR 1 (2), 324:A / RegBook 1 (2), 1943:K / Sax 6, 1158 / Structure Index 1, 312:A:8

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