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26564 Aldrich

Chlorotripyrrolidinophosphonium hexafluorophosphate

≥98.0% (AT)

Synonym: PyCloP

  • CAS Number 133894-48-1

  • Linear Formula C12H24ClN3P · PF6

  • Molecular Weight 421.73

  •  Beilstein Registry Number 6842341

  •  MDL number MFCD00210035

  •  PubChem Substance ID 24856093

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling,
InChI Key   BSCYRXJVGSZNKX-UHFFFAOYSA-N
assay   ≥98.0% (AT)
storage temp.   2-8°C

Description

Other Notes

Crystalline reagent for peptide coupling of N-alkylated N-Fmoc and N-Z amino acids in high yield and without racemization.

Packaging

5, 25 g in glass bottle

Application

Reagent for:
Peptide coupling reactions and synthesis of coupling reagents
Sequence selective peptide recognition
Synthesis of condensing reagents
Synthesis of heterocyclic β-sheet ligands

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1759 8 / PGII
WGK Germany 
3
Protocols & Articles

Articles

Phosphonium Salts

Phosphonium salts are powerful and easy-to-use peptide coupling reagents that allow in situ generation of active esters. After the recognition of chlorotris(dimethylamino)phosphonium as the activatin...
Matthias Junkers
Aldrich ChemFiles 2007, 7.2, 8.
Keywords: Chemfiles, Peptide synthesis

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COMU – Safer and More Efficient Peptide Coupling Reagent

Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Catalog, Condensations, Coupling reactions, Epimerizations, Methods, PEGylations, Peptide synthesis, Protocols, Racemizations, Search, Solid phase peptide synthesis, Solvents, Tools

Peer-Reviewed Papers
15

References

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