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269964 Aldrich

4-Nitroindole

97%

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Properties

Related Categories Building Blocks, C7 to C9, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
InChI Key   LAVZKLJDKGRZJG-UHFFFAOYSA-N
assay   97%
mp   205-207 °C(lit.)

Description

Packaging

1 g in glass bottle

Application

4-Nitroindole was used in the synthesis of 1,3,4,5-tetrahydropyrrolo-[4,3,2-de]quinoline.

Reactant for preparation of:
• Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
• Meridianin derivatives as protein kinase (PKC) inhibitors and vitro antiproliferative agents
• Anti-angiogenic agents
• Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
• Biologically active indoles
• CGRP receptor antagonists
• Nucleosides
• CB2 cannabinoid receptor ligands

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Indoles

Sigma-Aldrich is proud to offer a new series of ChemFiles—called Privileged Structures, to our Drug Discovery and Organic Synthesis customers. Each piece will highlight a specific motif, selected app...
Chemfiles Volume 4 Article 8
Keywords: Applications, Building blocks, Cardiovascular, Chemfiles, Company, Diabetes, Diseases, Drug discovery, Medicinal chemistry, Organic synthesis, Respiratory

Related Content

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

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