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270717 Aldrich

Acetonitrile

HPLC grade, ≥99.93%

Synonym: ACN, Methyl cyanide

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Properties

grade   HPLC grade
vapor density   1.41 (vs air)
vapor pressure   72.8 mmHg ( 20 °C)
assay   ≥99.93%
autoignition temp.   973 °F
purified by   sub-micron filtration
expl. lim.   16 %
gradient analysis   ≤0.005, 254nm
impurities   <0.005% water
evapn. residue   <0.0002%
refractive index   n20/D 1.344(lit.)
bp   81-82 °C(lit.)
mp   −48 °C(lit.)
  −48 °C
density   0.786 g/mL at 25 °C(lit.)
λ   H2O reference
UV absorption   λ: 190 nm Amax: 1.00
  λ: 200 nm Amax: 0.05
  λ: 210 nm Amax: 0.03
  λ: 220 nm Amax: 0.01
  λ: 235-400 nm Amax: 0.005

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
Risk Statements (Europe) 
Safety Statements (Europe) 
16-36/37
RIDADR 
UN 1648 3 / PGII
WGK Germany 
2
RTECS 
AL7700000
Flash Point(F) 
35.6 °F
Flash Point(C) 
2 °C

Protocols & Articles

Peer-Reviewed Papers

References

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An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter T Mol. Syst. Biol. 5, 237, (2009)

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A bioinspired redox relay that mimics radical interactions of the Tyr-His pairs of photosystem II. Megiatto JD, Méndez-Hernández DD, Tejeda-Ferrari ME, et al. Nature Chemistry 6(5), 423-8, (2014)

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Model-based design of peptide chromatographic purification processes. Gétaz D, Stroehlein G, Butté A, et al. J. Chromatogr. A 1284, 69-79, (2013)

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Modeling of mixed-mode chromatography of peptides. Bernardi S, Gétaz D, Forrer N, et al. J. Chromatogr. A 1283, 46-52, (2013)

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[Modified HPLC method of determination of the valproic acid in biological fluids]. Dutov AA, Nikitin DA, Letunov VI, et al. Biomed. Khim. 59(5), 514-8, (2013)

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[Measurement of acetonitrile in blood and urine by head-space gas chromatography]. Luo RX, Zhuo XY, and Shen BH Fa Yi Xue Za Zhi 28(6), 422-5, (2012)

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Theoretical studies for large tunneling and the hydrogen-transfer mechanism in the C-H activation of CH3CN by a di(μ-oxo)diiron(IV) complex: a model for intermediate Q in soluble methane monooxygenase. Khanh Mai B and Kim Y Chemistry 19(11), 3568-72, (2013)

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[Toxicology of acetonitrile]. Hashimoto K Sangyo. Igaku. 33(6), 463-74, (1991)

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An autocatalytic radical chain pathway in formation of an iron(IV)-oxo complex by oxidation of an iron(II) complex with dioxygen and isopropanol. Morimoto Y, Lee YM, Nam W, et al. Chem. Commun. (Camb.) 49(25), 2500-2, (2013)

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Amine modified graphene as reversed-dispersive solid phase extraction materials combined with liquid chromatography-tandem mass spectrometry for pesticide multi-residue analysis in oil crops. Guan W, Li Z, Zhang H, et al. J. Chromatogr. A 1286, 1-8, (2013)

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Direct analysis of intact glycidyl fatty acid esters in edible oils using gas chromatography-mass spectrometry. Steenbergen H, Hrnčiřík K, Ermacora A, et al. J. Chromatogr. A 1313, 202-11, (2013)

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Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection. Buscaglia R, Miller MC, Dean WL, et al. Nucleic Acids Res. 41(16), 7934-46, (2013)

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Optimisation of gradient elution with serially-coupled columns. Part I: single linear gradients. Ortiz-Bolsico C, Torres-Lapasió JR, and García-Alvarez-Coque MC J. Chromatogr. A 1350, 51-60, (2014)

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Another glimpse over the salting-out assisted liquid-liquid extraction in acetonitrile/water mixtures. Valente IM, Gonçalves LM, and Rodrigues JA J. Chromatogr. A 1308, 58-62, (2013)

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Determination of zolpidem in human hair by micropulverized extraction based on the evaluation of relative extraction efficiency of seven psychoactive drugs from an incurred human hair specimen. Miyaguchi H J. Chromatogr. A 1293, 28-35, (2013)

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Cyanide-arene Meisenheimer complex generated in electrospray ionization mass spectrometry using acetonitrile as a solvent. Chiavarino B, Maitre P, Fornarini S, et al. J. Am. Soc. Mass Spectrom. 24(10), 1603-7, (2013)

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Direct bacterial profiling by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for identification of pathogenic Neisseria. Elena N. Ilina et al J. Mol. Diagn. 11, 75-86, (2009)

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Preparation and characterization of open-tubular capillary column modified with graphene oxide nanosheets for the separation of small organic molecules. Xu YY, Niu XY, Dong YL, et al. J. Chromatogr. A 1284, 180-7, (2013)

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Approaches to model the retention and peak profile in linear gradient reversed-phase liquid chromatography. Baeza-Baeza JJ, Ortiz-Bolsico C, Torres-Lapasió JR, et al. J. Chromatogr. A 1284, 28-35, (2013)

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Effect of the ionic strength on the adsorption process of an ionic surfactant onto a C18-bonded charged surface hybrid stationary phase at low pH. Gritti F and Guiochon G J. Chromatogr. A 1282, 46-57, (2013)

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Effect of the pH and the ionic strength on overloaded band profiles of weak bases onto neutral and charged surface hybrid stationary phases in reversed-phase liquid chromatography. Gritti F and Guiochon G J. Chromatogr. A 1282, 113-26, (2013)

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Phosphopeptidomimetic substance libraries from multicomponent reaction: enantioseparation on quinidine carbamate stationary phase. Gargano AF, Lindner W, and Lämmerhofer M J. Chromatogr. A 1310, 56-65, (2013)

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Effect of pre-ozonation on the formation and speciation of DBPs. Hua G and Reckhow DA Water Res. 47(13), 4322-30, (2013)

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Toward prediction of alkane/water partition coefficients. Anita Toulmin et al J. Med. Chem. 51, 3720-30, (2008)

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Ionic liquid-mediated molecularly imprinted solid-phase extraction coupled with gas chromatography-electron capture detector for rapid screening of dicofol in vegetables. Yan H, Sun N, Han Y, et al. J. Chromatogr. A 1307, 21-6, (2013)

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Preparation and retention mechanism study of graphene and graphene oxide bonded silica microspheres as stationary phases for high performance liquid chromatography. Zhang X, Chen S, Han Q, et al. J. Chromatogr. A 1307, 135-43, (2013)

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Overloading study of basic compounds with a positively charged C18 column in liquid chromatography. Wang C, Guo Z, Long Z, et al. J. Chromatogr. A 1281, 60-6, (2013)

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High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation. Abigail L. Clutterbuck et al J. Proteomics 74, 704-15, (2011)

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Characterization and quantification of racemic and meso-ethylenediamine-N,N'-bis(2-hydroxy-5-sulfophenylacetic) acid/iron (III) by ion-pair ultra-high performance liquid chromatography coupled with diode array detector and electrospray tandem mass spectrometry. Biasone A, Cianci G, Di Tommaso D, et al. J. Chromatogr. A 1282, 142-52, (2013)

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Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation. Cimmino A PLoS ONE 3(9), e3258, (2008)

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Calculated and experimental chromatograms for distorted gradients and non-linear solvation strength retention models. Gritti F and Guiochon G J. Chromatogr. A 1356, 96-104, (2014)

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Separations by gradient elution: why are steep gradient profiles distorted and what is their impact on resolution in reversed-phase liquid chromatography. Gritti F and Guiochon G J. Chromatogr. A 1344, 66-75, (2014)

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Simultaneous determination of six resorcylic acid lactones in feed using liquid chromatography-tandem mass spectrometry and multi-walled carbon nanotubes as a dispersive solid phase extraction sorbent. Ying YF, Wu YL, Wen Y, et al. J. Chromatogr. A 1307, 41-8, (2013)

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Ultra high performance liquid chromatography/tandem mass spectrometry based identification of steroid esters in serum and plasma: an efficient strategy to detect natural steroids abuse in breeding and racing animals. Kaabia Z, Dervilly-Pinel G, Hanganu F, et al. J. Chromatogr. A 1284, 126-40, (2013)

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The hydrogen-bonded dianion of vitamin K1 produced in aqueous-organic solutions exists in equilibrium with its hydrogen-bonded semiquinone anion radical. Lim ZH, Chng EL, Hui Y, et al. J. Phys. Chem. B 117(8), 2396-402, (2013)

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Toward the accurate calculation of pKa values in water and acetonitrile. Muckerman JT, Skone JH, Ning M, et al. Biochim. Biophys. Acta 1827(8-9), 882-91, (2013)

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Analyses of polycyclic aromatic hydrocarbons in seafood by capillary electrochromatography-atmospheric pressure chemical ionization/mass spectrometry. Cheng YJ, Huang SH, Chiu JY, et al. J. Chromatogr. A 1313, 132-8, (2013)

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Detection and identification of hydrolysis products of sulfur mustards at trace levels in environmental samples using liquid chromatography solid phase extraction combined with off-line nuclear magnetic resonance analysis. Meier UC J. Chromatogr. A 1286, 159-65, (2013)

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In chemico evaluation of prohapten skin sensitizers: behavior of 2-methoxy-4-(¹³C)methylphenol in the peroxidase peptide reactivity assay (PPRA) as an alternative to animal testing. Merckel F, Giménez-Arnau E, Gerberick GF, et al. Toxicol. Lett. 218(3), 266-72, (2013)

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Design of experiments and multivariate analysis for evaluation of reversed-phase high-performance liquid chromatography with charged aerosol detection of sucrose caprate regioisomers. Lie A, Wimmer R, and Pedersen LH J. Chromatogr. A 1281, 67-72, (2013)

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Multiclass method for the determination of quinolones and β-lactams, in raw cow milk using dispersive liquid-liquid microextraction and ultra high performance liquid chromatography-tandem mass spectrometry. Junza A, Dorival-García N, Zafra-Gómez A, et al. J. Chromatogr. A 1356, 10-22, (2014)

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Poly[diacetonitrile-[μ(3)-difluoro-(oxalato)borato]sodium]. Allen JL, Boyle PD, and Henderson WA Acta Crystallogr. Sect. E Struct. Rep. Online 67(Pt 6), m678, (2011)

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Solvent-dependent molecular structure of ionic species directly measured by ultrafast x-ray solution scattering. Kim KH, Lee JH, Kim J, et al. Phys. Rev. Lett. 110(16), 165505, (2013)

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Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus. Zander J Infect. Immun. 76(4), 1333-9, (2008)

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Reduction and protonation of Mo(IV) imido complexes with depe coligands: generation and reactivity of a S = 1/2 Mo(III) alkylnitrene intermediate. Dreher A, Meyer S, Näther C, et al. Inorg. Chem. 52(5), 2335-52, (2013)

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In-capillary determination of creatinine with electrophoretically mediated microanalysis: characterization of the effects of reagent zone and buffer conditions. Phillip E. Mason et al J. Chromatogr. A 1216, 154-8, (2009)

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Surface excess isotherms of organic solvent mixtures in a system made of liquid carbon dioxide and a silicagel surface. Vajda P and Guiochon G J. Chromatogr. A 1308, 139-43, (2013)

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Direct-immersion solid-phase microextraction coupled to fast gas chromatography mass spectrometry as a purification step for polycyclic aromatic hydrocarbons determination in olive oil. Purcaro G, Picardo M, Barp L, et al. J. Chromatogr. A 1307, 166-71, (2013)

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The use of biopartitioning micellar chromatography and immobilized artificial membrane column for in silico and in vitro determination of blood-brain barrier penetration of phenols. Stępnik KE and Malinowska I J. Chromatogr. A 1286, 127-36, (2013)

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Evaluation of charged aerosol detector for purity assessment of protein. Wang R, Wang X, Paulino J, et al. J. Chromatogr. A 1283, 116-21, (2013)

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Bioanalytical solutions to acetonitrile shortages. Gao H, Williams J, Carrier S, et al. Bioanalysis 2(9), 1627-40, (2010)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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High-throughput phase-distribution method to determine drug-cyclodextrin binding constants. Chen Z J. Pharm. Sci. 98(1), 229-38, (2009)

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Nitric oxide reactivity of Cu(II) complexes of tetra- and pentadentate ligands: structural influence in deciding the reduction pathway. Kumar P, Kalita A, and Mondal B Dalton Trans. 42(16), 5731-9, (2013)

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Selective recognition of Pr3+ based on fluorescence enhancement sensor. Ganjali MR, Hosseini M, Ghafarloo A, et al. Mater. Sci. Eng. C. Mater. Biol. Appl. 33(7), 4140-3, (2013)

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Distribution of pesticides in n-hexane/water and n-hexane/acetonitrile systems and estimation of possibilities of their extraction isolation and preconcentration from various matrices. Zayats MF, Leschev SM, Petrashkevich NV, et al. Anal. Chim. Acta 774, 33-43, (2013)

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Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting. Krstulja A, De Schutter C, Favetta P, et al. J. Chromatogr. A 1365, 12-8, (2014)

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Adsorption of aqueous organic mixtures on a chiral stationary phase with bound antibiotic eremomycin. Nikitina YK, Ali I, and Asnin LD J. Chromatogr. A 1363, 71-8, (2014)

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Assessment of the complementarity of temperature and flow-rate for response normalisation of aerosol-based detectors. Khandagale MM, Hilder EF, Shellie RA, et al. J. Chromatogr. A 1356, 180-7, (2014)

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Performance of different C18 columns in reversed-phase liquid chromatography with hydro-organic and micellar-organic mobile phases. Ruiz-Angel MJ, Pous-Torres S, Carda-Broch S, et al. J. Chromatogr. A 1344, 76-82, (2014)

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Direct evidence of 2-cyano-2-propoxy radical activity during AIBN-based oxidative stress testing in acetonitrile-water solvent systems. Watkins MA, Pitzenberger S, and Harmon PA J. Pharm. Sci. 102(5), 1554-68, (2013)

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Photoluminescence and thermoanalytical studies of complexes based on 5-Cl-8-hydroxyquinoline and calix[4]arene ligands. Soares MN, Moscardini EF, Mercuri LP, et al. Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4), 2213-20, (2013)

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An acetonitrile-related death. Swanson JR and Krasselt WG J. Forensic Sci. 39(1), 271-9, (1994)

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Cyanide toxicity from acetonitrile-containing false nail remover. Geller RJ, Ekins BR, and Iknoian RC Am. J. Emerg. Med. 9(3), 268-70, (1991)

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RP-HPLC analytical method development and optimization for quantification of donepezil hydrochloride in orally disintegrating tablet. Liew KB, Peh KK, and Fung Tan YT Pak. J. Pharm. Sci. 26(5), 961-6, (2013)

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Enzymatic synthesis of long double-stranded DNA labeled with haloderivatives of nucleobases in a precisely pre-determined sequence. Sobolewski I, Polska K, Zylicz-Stachula A, et al. BMC Biochem. 12, 47, (2011)

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[Simultaneous determination of pesticide residues in agricultural products by LC-MS/MS]. Watanabe M, Ueno E, Inoue T, et al. Shokuhin Eiseigaku Zasshi 54(1), 14-24, (2013)

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Determination of linezolid in human serum by reversed-phase high-performance liquid chromatography with ultraviolet and diode array detection. Cios A, Kuś K, and Szymura-Oleksiak J Acta Pol. Pharm. 70(4), 631-41, (2013)

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Purity determination of gynalgin bactericidal tablets with HPLC method. Białecka W, Kulik A, Podolska M, et al. Acta Pol. Pharm. 70(1), 51-8, (2013)

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HPLC of flavanones and chalcones in different species and clones of Salix. Krauze-Baranowska M, Pobłocka-Olech L, Głód D, et al. Acta Pol. Pharm. 70(1), 27-34, (2013)

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Trace level determination of polyether ionophores in feed. Rokka M, Jestoi M, and Peltonen K Biomed Res. Int. 2013, 151363, (2013)

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Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography. Tran le N, Dixit S, and Park JH J. Chromatogr. A 1356, 289-93, (2014)

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Merck 14,70

Beil. 2,IV,419

Fieser 2,13

Aldrich MSDS 1, 13:C / Corp MSDS 1 (1), 22:A / FT-IR 2 (1), 1422:A / FT-IR 1 (1), 837:A / FT-NMR 1 (1), 1351:A / IR-Spectra (3), 1527:A / IR-Spectra (2), 444:A / IR-Spectra (3), 500:A / NMR-Reference 2 (1), 695:A / RegBook 1 (1), 987:A / Sax 6, 90 / Sigma FT-IR 1 (2), 233:C / Structure Index 1, 154:A:1 / Vapor Phase 3, 795:A

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34851 Acetonitrile, CHROMASOLV® gradient grade, for HPLC, ≥99.9%

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