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287644 Aldrich

(1R,2R)-(−)-Pseudoephedrine

98%

Synonym: α-(1-Methylaminoethyl)benzyl alcohol, (−)-ψ-Ephedrine, (−)-Pseudoephedrine, (1R,2R)-(−)-2-(Methylamino)-1-phenylpropanol, l-Pseudoephedrine

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Properties

Related Categories Alkaloid, Asymmetric Synthesis, Cell Biology, Chemical Synthesis, Chiral Auxiliaries,
InChI Key   KWGRBVOPPLSCSI-SCZZXKLOSA-N
assay   98%
optical activity   [α]20/D −51°, c = 0.6 in ethanol
mp   118-120 °C(lit.)

Description

Packaging

25, 100 g in glass bottle

Application

(1R,2R)-(-)-Pseudoephedrine may be used in the preparation of chiral relay ligands, which can catalyze the addition of diethylzinc to aldehydes leading to the corresponding secondary alcohol. The immobilization of pseudoephedrine on Merrifield resin forms a chiral linker, which may be used for the asymmetric alkylation of amides via solid-phase approach.

General description

(1R,2R)-(-)-Pseudoephedrine is an enantiomer of ephedrine mainly used as a chiral auxiliary for asymmetric synthesis.

Price and Availability


Laboratory Gloves

All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UL5750500
Protocols & Articles

Articles

Ephedrines

Both enantiomers of ephedrine, pseudoephedrine, norephedrine, and their derivatives are used as practical chiral auxiliaries for asymmetric synthesis. Enolates of readily available (1R,2R)-(–)- and (...
Aldrich ChemFiles 2005, 5.4, 9.
Keywords: Alkylations, Asymmetric synthesis, Chemfiles, Chiral auxiliaries

HPLC Analysis of Pseudoephedrine Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Pseudoephedrine Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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