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305995 Aldrich

2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphorodiamidite

97%

Synonym: Bis(diisopropylamino)(2-cyanoethoxy)phosphine

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Properties

Related Categories Building Blocks, Chemical Biology, Chemical Synthesis, Coupling Reagents, Nucleoside Chemistry,
InChI Key   RKVHNYJPIXOHRW-UHFFFAOYSA-N
assay   97%
refractive index   n20/D 1.470(lit.)
bp   100 °C/0.5 mmHg(lit.)
density   0.949 g/mL at 25 °C(lit.)
storage temp.   −20°C

Description

Packaging

1, 5 g in glass bottle

Application

2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite was used:
• in preparation of prosphoramidite reagent, required for synthesis of 12-mer oligodeoxynucleotide
• as phosphorylating agent in synthesis of 1,2-diacyl-sn-glycerophosphatidylserine
• in situ preparation of deoxyribonucleoside phosphoramidites
• in preparation of 2′-deoxy-2′-fluoro-3′-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-5′-O-(4-methoxytrityl)-4′-thio-β-D-arabinouridine and 1-(3-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-2-deoxy-2-fluoro-5-O-(4,4′-dimethoxytrityl)-4-thio-β-D-arabinofuranosyl)-thymine
• as reagent for synthesizing phosphitylated nucleotides

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 1993C 3 / PGIII
WGK Germany 
3
Flash Point(F) 
140 °F
Flash Point(C) 
60 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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