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323586 Aldrich

Dioctyl sulfosuccinate sodium salt

≥97%

Synonym: AOT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, DOSS, Docusate sodium

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Description

Application

Surfactant.1

Used to make a microemulsion with CAPSO for the electrophoresis detection of natural and synthetic estrogens.

Used to prepare reverse micelles.

Packaging

1 kg in poly bottle

5, 25, 100, 500 g in poly bottle

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
2

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. Aerosol-OT-gamma-alumina admicelles for the concentration of hydrophobic organic compounds in water. J. Chromatogr. A. 1040, 185-191, (2004)

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Kagaku Kogyo 55, 263-267, (2004)

Simultaneous determination of natural and synthetic estrogens by EKC using a novel microemulsion. Electrophoresis 27, 4431, (2006)

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Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: a systematic review. Ruston T, Hunter K, Cummings G, et al. Can. Oncol. Nurs. J. 23(4), 236-46, (2013)

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Assessment of the ototoxicity of docusate sodium (colace) in a guinea pig animal model. Emami N, Ng B, Roskies M, et al. J. Otolaryngol. Head Neck Surg. 41(5), 316-9, (2012)

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Comparison between two anionic reverse micelle interfaces: the role of water-surfactant interactions in interfacial properties. Quintana SS, Falcone RD, Silber JJ, et al. ChemPhysChem 13(1), 115-23, (2012)

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Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology. George M and Ghosh I Eur. J. Pharm. Sci. 48(1-2), 142-52, (2013)

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Dioctyl sulfosuccinate analysis in near-shore Gulf of Mexico water by direct-injection liquid chromatography-tandem mass spectrometry. Mathew J, Schroeder DL, Zintek LB, et al. J. Chromatogr. A 1231, 46-51, (2012)

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A molecular dynamics study of structure, stability and fragmentation patterns of sodium bis(2-ethylhexyl)sulfosuccinate positively charged aggregates in vacuo. Longhi G, Abbate S, Ceraulo L, et al. Phys. Chem. Chem. Phys. 13(48), 21423-31, (2011)

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Aggregation behavior of sodium dioctylsulfosuccinate in aqueous ethylene glycol medium. A case of hydrogen bonding between surfactant and solvent and its manifestation in the surface tension isotherm. Das D, Dey J, Chandra AK, et al. Langmuir 28(45), 15762-9, (2012)

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Evidence for a critical micelle concentration of surfactants in hydrocarbon solvents. Smith GN, Brown P, Rogers SE, et al. Langmuir 29(10), 3252-8, (2013)

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Ototoxicity of intratympanic docusate sodium and mineral oil in the guinea pig. Nader ME and Saliba I Otolaryngol. Head Neck Surg. 146(3), 455-60, (2012)

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Correlating proton transfer dynamics to probe location in confined environments. Sedgwick M, Cole RL, Rithner CD, et al. J. Am. Chem. Soc. 134(29), 11904-7, (2012)

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Irradiation induced fluorescence enhancement in PEGylated cyanine-based NIR nano- and mesoscale GUMBOS. Lu C, Das S, Magut PK, et al. Langmuir 28(40), 14415-23, (2012)

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Bowel function after minimally invasive urogynecologic surgery: a prospective randomized controlled trial. McNanley A, Perevich M, Glantz C, et al. Female Pelvic Med. Reconstr. Surg. 18(2), 82-5, (2012)

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Inhibited phenol ionization in reverse micelles: confinement effect at the nanometer scale. Silva OF, Fernández MA, Silber JJ, et al. ChemPhysChem 13(1), 124-30, (2012)

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Self nanoprecipitating preconcentrate of tamoxifen citrate for enhanced bioavailability. Kapse SV, Gaikwad RV, Samad A, et al. Int. J. Pharm. 429(1-2), 104-12, (2012)

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Myoglobin unfolding in crowding and confinement. Malik A, Kundu J, Mukherjee SK, et al. J. Phys. Chem. B 116(43), 12895-904, (2012)

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Urea effect on aggregation and adsorption of sodium dioctylsulfosuccinate in water. Thapa U and Ismail K J. Colloid. Interface Sci. 406, 172-7, (2013)

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Nanoconfinement of water layers in lamellar structures prepared in the presence and absence of organic solvent. De D, Sajjan M, Narayanan J, et al. J. Phys. Chem. B 117(7), 2106-12, (2013)

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Two- and three-dimensional standing waves in a reaction-diffusion system. Bánsági T, Vanag VK, and Epstein IR Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. 86(4 Pt 2), 045202, (2012)

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Distribution of polyphenols and a surfactant component in skin during Aerosol OT microemulsion-enhanced intradermal delivery. Yutani R, Morita SY, Teraoka R, et al. Chem. Pharm. Bull. 60(8), 989-94, (2012)

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Mass spectrometry study of multiply negatively charged, gas-phase NaAOT micelles: how does charge state affect micellar structure and encapsulation? Fang Y, Liu F, and Liu J J. Am. Soc. Mass Spectrom. 24(1), 9-20, (2013)

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Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications. Nesamony J, Zachar CL, Jung R, et al. Drug Dev. Ind. Pharm. 39(2), 240-51, (2013)

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Protein recovery from surfactant precipitation. Cheng SI and Stuckey DC Biotechnol. Prog. 27(6), 1614-22, (2011)

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Phase and sedimentation behavior of oil (octane) dispersions in the presence of model mineral aggregates. Gupta A, Sender M, Fields S, et al. Mar. Pollut. Bull. 87(1-2), 164-70, (2014)

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Surfactant choice and the physical stability of nanosuspensions as a function of pH. Donoso MD, Haskell RJ, and Schartman RR Int. J. Pharm. 439(1-2), 1-7, (2012)

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Quenching of the triplet state of Safranine-O by aliphatic amines in AOT reverse micelles studied by transient absorption spectroscopy. Porcal GV, Chesta CA, Biasutti MA, et al. Photochem. Photobiol. Sci. 11(2), 302-8, (2012)

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Gel formulation containing mixed surfactant and lipids associating with carboplatin. Woll KA, Schuchardt EJ, et al. Chem. Biodivers. 8, 2195-2210, (2011)

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[World constructed by self-organization of some amphiphils--with a focus on vesicle formation--]. Ueno M Yakugaku Zasshi 131(12), 1765-79, (2011)

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Wretched excess: stool-softener abuse and cardiogenic shock. Frisoli TM, Swistel DG, Makani H, et al. Am. J. Med. 126(9), 773-5, (2013)

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A facile way to fabricate polyester microcapsules. Yu X and Zhu J J. Control. Release 152 Suppl 1, e128-9, (2011)

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Merck 14,3401

Beil. 4,III,71

Fieser 15,149

Aldrich MSDS 1, 819:A / Corp MSDS 1 (1), 1445:C / FT-IR 1 (1), 897:D / FT-IR 2 (1), 1520:A / IR-Spectra (2), 477:H / IR-Spectra (3), 540:B / NMR-Reference 2 (2), 799:A / RegBook 1 (1), 1065:H / Sax 6, 1017 / Structure Index 1, 166:D:1

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