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343536 Aldrich

1-Boc-piperazine

97%

Synonym: tert-Butyl piperazine-1-carboxylate

  • CAS Number 57260-71-6

  • Empirical Formula (Hill Notation) C9H18N2O2

  • Molecular Weight 186.25

  •  Beilstein Registry Number 879985

  •  MDL number MFCD00075265

  •  PubChem Substance ID 24861171

  • Popular Documents:  FTNMR (PDF)  

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Properties

Related Categories Building Blocks, C9, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines More...
InChI Key   CWXPZXBSDSIRCS-UHFFFAOYSA-N
assay   97%
mp   43-47 °C(lit.)

Description

Application

1-Boc-piperazine may be used in:
• preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
• termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
• preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors

Packaging

1, 5, 25 g in glass bottle

General description

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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