EMAIL THIS PAGE TO A FRIEND
343536 Aldrich

1-Boc-piperazine

97%

Synonym: tert-Butyl piperazine-1-carboxylate

  • CAS Number 57260-71-6

  • Empirical Formula (Hill Notation) C9H18N2O2

  • Molecular Weight 186.25

  •  Beilstein Registry Number 879985

  •  MDL number MFCD00075265

  •  PubChem Substance ID 24861171

  • Popular Documents:  FTNMR (PDF)  

Purchase

Properties

Related Categories Building Blocks, C9, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines More...
InChI Key   CWXPZXBSDSIRCS-UHFFFAOYSA-N
assay   97%
mp   43-47 °C(lit.)

Description

Application

1-Boc-piperazine may be used in:
• preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
• termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
• preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors

Packaging

1, 5, 25 g in glass bottle

General description

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?