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348333 Aldrich

tert-Butyl diethylphosphonoacetate

95%

Synonym: (Diethoxyphosphinyl)acetic acid 1,1-dimethylethyl ester, tert-Butyl (diethoxyphosphinyl)acetate, Diethyl tert-butoxycarbonylmethanephosphonate

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Horner-Wadsworth-Emmons Reagents, Olefination, Synthetic Reagents More...
InChI Key   NFEGNISFSSLEGU-UHFFFAOYSA-N
assay   95%
refractive index   n20/D 1.431(lit.)
bp   100-103 °C/1.5 mmHg(lit.)
density   1.074 g/mL at 25 °C(lit.)

Description

Packaging

5 g in glass bottle

Application

Reactant for:
• Preparation of ydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents
• Synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3)
• One-pot synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether
• Bicyclic triaminophosphine-promoted stereoselective synthesis of a,ß-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates
• Preparation of amidopropenyl hydroxamates as human histone deacetylase (HDAC) inhibitors

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
>235.4 °F
Flash Point(C) 
>113 °C
Protocols & Articles
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