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349631 Aldrich

Dimethyl 2-oxoglutarate

96%

Synonym: Dimethyl α-ketoglutarate

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Properties

Related Categories Building Blocks, C6 to C7, Cancer Metabolism, Cancer Research, Carbonyl Compounds,
InChI Key   TXIXSLPEABAEHP-UHFFFAOYSA-N
assay   96%
refractive index   n20/D 1.439(lit.)
bp   90-95 °C/0.4 mmHg(lit.)
density   1.203 g/mL at 25 °C(lit.)

Description

Packaging

5 g in glass bottle

Application

Dimethyl 2-oxoglutarate may be used to synthesize the conformationally constrained PNA (peptide nucleic acid) -monomer capable of binding thymine in a triplex motif. It may be used in the synthesis of 4-aryl kainic acid analogs, via highly stereoselective Michael addition reaction with nitrostyrene.

General description

Dimethyl 2-oxoglutarate is a key intermediate formed during the Krebs cycle and an important nitrogen transporter in the biological metabolic pathways. The electrochemical behavior of dimethyl-2-oxoglutarate has been investigated by cyclic voltammetry, square wave voltammetry and differential pulse voltammetry using a glassy carbon electrode.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
>235.4 °F
Flash Point(C) 
>113 °C
Protocols & Articles

Articles

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
Keywords: Aerobic, Biofiles, Cancer, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Metabolites, PAGE, Phosphorylations, Support, Transcription

Peer-Reviewed Papers
15

References

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