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357987 Aldrich

1-Methylindole-3-carboxaldehyde

97%

Synonym: 3-Formyl-1-methylindole, NSC 83042

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Properties

Related Categories Aldehydes, Building Blocks, C10, C10-C12, Carbonyl Compounds,
InChI Key   KXYBYRKRRGSZCX-UHFFFAOYSA-N
assay   97%
mp   70-72 °C(lit.)

Description

Packaging

5, 25 g in glass bottle

Application

• Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions
• Reactant for synthesis of quinolinones via three-component Ugi reaction
• Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture
• Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins
• Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent
• Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents

1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).

General description

1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Indoles

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Peer-Reviewed Papers
15

References

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