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359181 Aldrich

Tetraethyl methylenediphosphonate

97%

Synonym: Bis(diethoxyphosphinyl)methane, Methylenediphosphonic acid tetraethylester, NSC 133889

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Horner-Wadsworth-Emmons Reagents, Olefination, Synthetic Reagents More...
InChI Key   STJWVOQLJPNAQL-UHFFFAOYSA-N
assay   97%
refractive index   n20/D 1.442(lit.)
bp   171-174 °C/11 mmHg(lit.)
density   1.16 g/mL at 25 °C(lit.)

Description

Packaging

5, 25 mL in glass bottle

Application

Reactant for synthesis of:
• Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
• Unnatural alpha-amino acid derivatives containing gem-biphosphonates
• Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
• Lycopene via Wittig-Horner reaction
• Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
• Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase

Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
SZ9150000
Flash Point(F) 
230 °F
Flash Point(C) 
110 °C
Protocols & Articles
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