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359734 Aldrich

Calcium citrate tetrahydrate


Synonym: Tricalcium dicitrate tetrahydrate




1 kg in poly bottle

250 g in poly bottle


Calcium citrate tetrahydrate may be used as raw material in the preparation of nanoparticle with the nominal composition Ca0.8 Ba0.2 Ti03 :Pr3+, via sol-gel process.1 It may be employed as carbon source in a simple and effective carbonization method to prepare porous carbon without any activation process.2 It is suitable for use in the preparation of bovine serum albumin (BSA) nanoparticles.3

General description

Thermal decomposition of calcium citrate tetrahydrate in dynamic air or dry nitrogen has been investigated by by TG, DTA and DSC.4

Price and Availability

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Safety & Documentation

Safety Information

WGK Germany 

Protocols & Articles

Peer-Reviewed Papers


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1. Effect of sintering temperature on the luminescence properties of Ca0.8 Ba0.2 TiO3 :Pr(3+) red-emitting phosphor. Mu Y, Qiu M, Zhou X, et al. Luminescence, doi:10.1002/bio.2767, (2014)


2. An activation-free protocol for preparing porous carbon from calcium citrate and the capacitive performance. Zhou QQ, et al. Microporous Mesoporous Mater. 158, 155-61, (2012)

3. Preparation of size-controlled bovine serum albumin (BSA) nanoparticles by a modified desolvation method. Jun JY, et al. Food Chem. 127(4), 1892-98, (2011)

4. Thermal decomposition of calcium citrate tetrahydrate. Mansour SAA. Thermochim. Acta 233(2), 243-56, (1994)

Acute effects of calcium carbonate, calcium citrate and potassium citrate on markers of calcium and bone metabolism in young women. Karp HJ, Ketola ME, and Lamberg-Allardt CJ Br. J. Nutr. 102(9), 1341-7, (2009)


Recalcitrant hypocalcaemia in autoimmune enteropathy. Geyer M, Fairchild J, Moore D, et al. Pediatrics 134(6), e1720-6, (2014)


Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health sarcopenia project. Fragala MS, Dam TT, Barber V, et al. J. Gerontol. A. Biol. Sci. Med. Sci. 70(2), 202-9, (2015)


[Study indites calcium as a heart breaker. 30 % more myocardial infarcts caused by high dosage calcium preparations]. Kinderkrankenschwester 32(3), 114, (2013)


[General and local factors affecting periapical reparation after endodontic procedures]. Prilukova NA and Redinova TL Stomatologiia. (Mosk.) 91(4), 11-5, (2012)


[Calcium suppletion for patients who use gastric acid inhibitors: calcium citrate or calcium carbonate?]. de Jonge HJ, Gans RO, and Huls G Ned. Tijdschr. Geneeskd. 156(34), A4343, (2012)


In brief: only the name remains the same. Med. Lett. Drugs Ther. 52(1341), 49, (2010)


The effect of vitamin D on calcium absorption in older women. Gallagher JC, Yalamanchili V, and Smith LM J. Clin. Endocrinol. Metab. 97(10), 3550-6, (2012)


Acute effect of calcium citrate on serum calcium and cardiovascular function. Burt MG, Mangelsdorf BL, Srivastava D, et al. J. Bone Miner Res. 28(2), 412-8, (2013)


Biochemical control of bone loss and stone-forming propensity by potassium-calcium citrate after bariatric surgery. Sakhaee K, Griffith C, and Pak CY Surg. Obes. Relat. Dis. 8(1), 67-72, (2012)


Secondary prevention of osteoporosis in Australia: analysis of government-dispensed prescription data. Hollingworth SA, Gunanti I, Nissen LM, et al. Drugs Aging 27(3), 255-64, (2010)


Calcium citrate and vitamin D in the treatment of osteoporosis. Quesada Gómez JM, Blanch Rubió J, Díaz Curiel M, et al. Clin. Drug Investig. 31(5), 285-98, (2011)


Hormone replacement after thyroid and parathyroid surgery. Schäffler A Dtsch. Arztebl. Int. 107(47), 827-34, (2010)


Absorption of levothyroxine when coadministered with various calcium formulations. Zamfirescu I and Carlson HE Thyroid 21(5), 483-6, (2011)


Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model. Huang S, Chen JC, Hsu CW, et al. Nanotechnology 20(37), 375102, (2009)


Anticaries effect of dentifrices with calcium citrate and sodium trimetaphosphate. Delbem AC, Bergamaschi M, Rodrigues E, et al. J. Appl. Oral Sci. 20(1), 94-8, (2012)


Enhancement of bone formation with a synthetic matrix containing bone morphogenetic protein-2 by the addition of calcium citrate. Wang W, Chen Q, Li X, et al. Knee Surg. Sports Traumatol. Arthrosc. 21(2), 456-65, (2013)


Calcium supplements lower bone resorption after renal transplant. Yu RW, Faull RJ, Coates PT, et al. Clin. Transplant. 26(2), 292-9, (2012)


Compound ion salt, a novel low-sodium salt substitute: from animal study to community-based population trial. Zhou X, Liu JX, Shi R, et al. Am. J. Hypertens. 22(9), 934-42, (2009)


Intravenous ibandronate or sodium-fluoride--a 3.5 years study on bone density and fractures in Crohn's disease patients with osteoporosis. Klaus J, Reinshagen M, Herdt K, et al. J. Gastrointestin. Liver Dis. 20(2), 141-8, (2011)


Bones and Crohn's: no benefit of adding sodium fluoride or ibandronate to calcium and vitamin D. Klaus J, Reinshagen M, Herdt K, et al. World J. Gastroenterol. 17(3), 334-42, (2011)


Comparative effects of a novel plant-based calcium supplement with two common calcium salts on proliferation and mineralization in human osteoblast cells. Adluri RS, Zhan L, Bagchi M, et al. Mol. Cell Biochem. 340(1-2), 73-80, (2010)


Thiazide-induced severe hypercalcemia: a case report and review of literature. Desai HV, Gandhi K, Sharma M, et al. Am. J. Ther. 17(6), e234-6, (2010)


Prenatal effects of natural calcium supplement on Wistar rats during organogenesis period of pregnancy. Lagarto A, Bellma A, Couret M, et al. Exp. Toxicol. Pathol. 65(1-2), 49-53, (2013)


Effect of calcium citrate on bone integration in a rabbit femur defect model. Zhang W, Wang W, Chen QY, et al. Asian Pac. J. Trop. Med. 5(4), 310-4, (2012)


A model for calcium permeation into small intestine. Dolinska B, Mikulska A, Caban A, et al. Biol. Trace Elem. Res. 142(3), 456-64, (2011)


PPIs and fracture risk. Med. Lett. Drugs Ther. 55(1410), 15-6, (2013)


Merck 14,1661

Beil. 3,564

FT-IR 2 (1), 888:C / FT-NMR 1 (1), 860:B / RegBook 1 (1), 633:C / Structure Index 1, 92:B:6

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