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  • 37345 - O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

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37345 Aldrich

O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

≥95.0% (HPLC)

Synonym: N,N,N′,N′-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, O-(4-Oxo-1,2,3-benzotriazin-3(4H)-yl)-N,N,N′,N′,-tetramethyluronium tetrafluoroborate, TDBTU

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Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Triazines
InChI Key   FOBCPCIJLQTYBT-UHFFFAOYSA-N
assay   ≥95.0% (HPLC)
solubility   acetonitrile: soluble0.1 g/mL, clear
storage temp.   2-8°C

Description

Packaging

1 g in glass bottle

Application

O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as:
• coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers
• condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647)
• coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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