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373605 Aldrich

6,6′-Dithiodinicotinic acid

technical grade, 85%

Synonym: Bis[3-Carboxypyridine] 6,6′-disulfide, Bis[3-carboxypyridine] 6,6′-disulfide

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Properties

Related Categories Building Blocks, C12, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines More...
grade   technical grade
InChI Key   GSASOFRDSIKDSN-UHFFFAOYSA-N
assay   85%
mp   263-265 °C(lit.)

Description

Packaging

5 g in glass bottle

Application

6,6′-Dithiodinicotinic acid may be employed as:
• specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
• modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
• dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
• water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
• chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
• spectrophotometric determination of thiols and of total glutathione in human blood

General description

6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
US5684700
Protocols & Articles
Peer-Reviewed Papers
15

References

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