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374539 Aldrich

Dimethyl chloromalonate

94%

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Properties

Related Categories Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters,
InChI Key   LNBQBURECUEBKZ-UHFFFAOYSA-N
assay   94%
impurities   4-5% dimethyl dichloromalonate
refractive index   n20/D 1.437(lit.)
bp   105-106 °C/19 mmHg(lit.)
density   1.305 g/mL at 25 °C(lit.)

Description

Packaging

25, 100 g in glass bottle

Application

Dimethyl chloromalonate is suitable for use in the synthesis of 4,5,6-trichloropyrimidine. It may be used in the stereoselective synthesis of highly functionalized nitrocyclopropanes. It may be used in one-pot synthesis of tetra-alkoxycarbonylallylidenetriphenylphosphoranes.

General description

Dimethyl chloromalonate (dimethyl 2-chloromalonate) is a dialkyl 2-substituted malonate. Carbanions of dimethyl chloromalonate are reported to react with naphthoquinone derivatives, via vicarious nucleophilic substitution or oxidative nucleophilic substitution of hydrogen processes. Dimethyl chloromalonate is reported to react with hydroquinone and monosubstituted hydroquinones to afford 2-oxido-benzo[b]furan derivatives. Synthesis of dimethyl 2-chloromalonate, via chlorination of dimethyl malonate has been reported.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3265 8 / PGII
WGK Germany 
3
Flash Point(F) 
224.6 °F
Flash Point(C) 
107 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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