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376868 Aldrich

2-(2-Aminophenyl)indole

97%

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Properties

Related Categories Building Blocks, C13 to C27, Chemical Synthesis, Heterocyclic Building Blocks, Indoles More...
InChI Key   IAKRGXQCKYFJCB-UHFFFAOYSA-N
assay   97%
mp   154-155 °C(lit.)

Description

Application

2-(2-Aminophenyl)indole may be used in the preparation of novel indolo[1,2-c]quinazolines and benzimidazo[1,2-c]quinazolines. It may be used in the synthesis of mono and bis-indolo[1,2-c] quinazolines.

Reactant in:
• cascade reactions of benzopyranylidenemalonates with mono- and dinucleophiles

Reactant for preparation of:
• Mono-, bis-indolo[1,2-c]quinazolines as antimicrobial agents
• Isocryptolepine alkaloid with antimalarial activity
• Cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines as antitumor agents

General description

2-(2-Aminophenyl)indole is an indole derivative. It has been reported as an amination reagent. 2-(2-Aminophenyl)indole undergoes condensation with 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) to afford new 6-cyanoindolo[3,2-c]quinoline derivatives, having pharmacological applications.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Indoles

Sigma-Aldrich is proud to offer a new series of ChemFiles—called Privileged Structures, to our Drug Discovery and Organic Synthesis customers. Each piece will highlight a specific motif, selected app...
Chemfiles Volume 4 Article 8
Keywords: Applications, Building blocks, Cardiovascular, Chemfiles, Company, Diabetes, Diseases, Drug discovery, Medicinal chemistry, Organic synthesis, Respiratory

Related Content

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

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