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377848 Aldrich

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

98%

Synonym: PyBOP®

  • CAS Number 128625-52-5

  • Linear Formula C18H28N6OP · PF6

  • Molecular Weight 520.39

  •  Beilstein Registry Number 3584612

  •  MDL number MFCD00077411

  •  PubChem Substance ID 24863525

  • Popular Documents:  FTNMR (PDF)  

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling,
InChI Key   VIAFLMPQBHAMLI-UHFFFAOYSA-N
assay   98%
mp   154-156 °C (dec.)(lit.)
storage temp.   2-8°C

Description

Application

Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.

Reagent for:
Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization
Generation of endocrine disruptor chemical binders
Cycloaddition to template-assembled multivalent peptide conjugates

Packaging

1, 5 g in glass bottle

Legal Information

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Price and Availability


Laboratory Gloves

Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Phosphonium Salts

Phosphonium salts are powerful and easy-to-use peptide coupling reagents that allow in situ generation of active esters. After the recognition of chlorotris(dimethylamino)phosphonium as the activatin...
Matthias Junkers
Aldrich ChemFiles 2007, 7.2, 8.
Keywords: Chemfiles, Peptide synthesis

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Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
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Peer-Reviewed Papers
15

References

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