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380563 Aldrich

2-Amino-5-methylthiazole

98%

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Properties

Related Categories Building Blocks, C3 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Thiazoles More...
assay   98%
mp   93-98 °C(lit.)

Description

Packaging

5, 25 g in glass bottle

Application

2-Amino-5-methylthiazole may be used in the preparation of mixed-ligand dien-Cu(II) complexes (dien=diethylenetriamine).1 It may be used in the preparation of a new series of Schiff mono/dibase coordination compounds, having potential anticancer and antibacterial activities.2,3,4

General description

2-Amino-5-methylthiazole is a heterocyclic building block. Thermodynamics of binding of 2-amino-5-methylthiazole to the W191G cavity mutant of cytochrome c peroxidase has been reported.5 It is one of the major alkaline degradation product of tenoxicam (TX) and meloxicam (MX).6

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Meloxicam impurity B

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Risk Statements (Europe) 
Safety Statements (Europe) 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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1. Antiproliferative activity of mixed-ligand dien-Cu(II) complexes with thiazole, thiazoline and imidazole derivatives. Bolos CA, Papazisis KT, Kortsaris AH, et al. J. Inorg. Biochem. 88(1), 25-36, (2002)

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2. Copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole: synthesis, characterization, antiproliferative and antibacterial studies. Crystal structure of CudienOOCl2. Chaviara AT, Cox PJ, Repana KH, et al. J. Inorg. Biochem. 98(8), 1271-83, (2004)

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3. The unexpected formation of biologically active Cu(II) Schiff mono-base complexes with 2-thiophene-carboxaldehyde and dipropylenetriamine: crystal and molecular structure of CudptaSCl2. Chaviara AT, Cox PJ, Repana KH, et al. J. Inorg. Biochem. 99(2), 467-76, (2005)

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4. Evaluation of anti-inflammatory and antioxidant activities of copper (II) Schiff mono-base and copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole. Pontiki E, Hadjipavlou-Litina D, and Chaviara AT J. Enzyme Inhib. Med. Chem. 23(6), 1011-7, (2008)

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5. (Thermo)dynamic role of receptor flexibility, entropy, and motional correlation in protein-ligand binding. Baron R and McCammon JA ChemPhysChem 9(7), 983-8, (2008)

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6. Ratio derivative spectrophotometric method for the determination of some oxicams in presence of their alkaline degradation products. Taha EA, et al. Sci. Pharm. 71(4), 303-20, (2003)

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase. Tania Castaño et al Bioorg. Med. Chem. 16, 6193-206, (2008)

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Beil. 27,IV,4741

FT-IR 2 (3), 3555:D / FT-NMR 1 (3), 114:C / RegBook 1 (2), 2387:H / Structure Index 1, 379:C:1

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