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411361 Aldrich

Diethyl (bromodifluoromethyl)phosphonate

96%

Synonym: (Bromodifluoromethyl)phosphonic acid diethyl ester

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Horner-Wadsworth-Emmons Reagents, Olefination, Synthetic Reagents More...
InChI Key   QRADKVYIJIAENZ-UHFFFAOYSA-N
assay   96%
refractive index   n20/D 1.417(lit.)
bp   40-41 °C/0.05 mmHg(lit.)
density   1.503 g/mL at 25 °C(lit.)

Description

Packaging

5 g in glass bottle

Application

Reactant for:
• Preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3)
• Synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps
• P-C bond cleavage on basic hydrolysis
• Preparation of a prodrug for intracellular delivery of protein tyrosine phosphatase 1B (PTP1B) inhibitor (nonhydrolyzable difluoromethylphosphonate moiety)

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
>235.4 °F
Flash Point(C) 
>113 °C
Protocols & Articles
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