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414131 Aldrich

1-Bromopinacolone

≥97%

Synonym: 1-Bromo-3,3-dimethyl-2-butanone, Bromomethyl tert-butyl ketone

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Properties

Related Categories Building Blocks, C3 to C6, Carbonyl Compounds, Chemical Synthesis, Ketones,
InChI Key   SAIRZMWXVJEBMO-UHFFFAOYSA-N
assay   ≥97%
refractive index   n20/D 1.466(lit.)
bp   188-194 °C(lit.)
mp   −10 °C(lit.)
density   1.331 g/mL at 25 °C(lit.)
storage temp.   −20°C

Description

Packaging

5, 25 mL in glass bottle

Application

1-Bromopinacolone is the suitable reagent for the synthesis of a photolabile azido derivative of the kaurene oxidase inhibitor 1-(4- chlorophenyl)4,4-dimethyl-2-(1,2,4-triazol-1-yl) pentan-3-ol (paclobutrazol). It may be used as reagent in the synthesis of 2-t-butyl-6-benzoylimidazo[1,2-b]pyridazine.

General description

1-Bromopinacolone is an α-bromoketone-aldehyde. Coupling of 1-bromopinacolone with various aldehyde electrophiles catalyzed by SmI2 has been reported. It acts as reversible competitive inhibitor for acetylcholinesterase, during hydrolysis of acetylcholine.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3334
WGK Germany 
3
RTECS 
EL7010000
Flash Point(F) 
167 °F
Flash Point(C) 
75 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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