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415324 Aldrich

N-Isopropylacrylamide

97%

Synonym: NIPAM

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Properties

Related Categories Acrylamide and Methacrylamide, Acrylic Monomers, Materials Science, Monomers, Polymer Science More...
assay   97%
bp   89-92 °C/2 mmHg(lit.)
mp   60-63 °C(lit.)

Description

Application

N-Isopropylacrylamide is used to produce poly(N-isopropylacrylamide) (pNIPA, pNIPAAm, pNIPAA or pNIPAm) thermosensitive polymer- or copolymer-based hydrogels. Polymers that contain NIPAM shrink dramatically above 33 °C.

Monomer used in the preparation of thermally sensitive, water-swellable hydrogels.

Packaging

10, 50 g in poly bottle

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
26
WGK Germany 
3
RTECS 
AS3675000

Protocols & Articles

Articles

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.1 Nonetheless, major challenges still need ...
Masamichi NakayamaTeruo Okano and Françoise M. Winnik
Material Matters 2010, 5.3, 56.
Keywords: Adhesion, Applications, Biomaterials, Cell culture, Clinical, Dehydration reaction, Growth factors, Hydration reaction, Immobilization, Inflammation, Ligands, Magnetic resonance spectroscopy, Material Matters, Polymerization reactions, Radical polymerization, Rearrangements, Reversible addition-fragmentation chain transfer polymerizations, Solvents

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Light-triggered concomitant enhancement of magnetic resonance imaging contrast performance and drug release rate of functionalized amphiphilic diblock copolymer micelles. Li Y, Qian Y, Liu T, et al. Biomacromolecules 13(11), 3877-86, (2012)

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Photoisomerizable and thermoresponsive N-isopropylacrylamide-surfmer copolymer hydrogels prepared upon electrostatic self-assembly of an azobenzene bolaamphiphile. Friedrich T, Mielke T, Domogalla M, et al. Macromol. Rapid Commun. 34(5), 393-8, (2013)

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Meunier, F., Elaissari, A. Surf. Sci. Ser. 115, 117, (2003)

Saunders, B.R. Surf. Sci. Ser. 115, 419, (2003)

[Controlled release using temperature-responsive poly(N-isopropylacrylamide) gel]. Yoshida R Nihon Rinsho. 56(3), 670-4, (1998)

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CORR Insights®: distribution of locally delivered antimicrobials is limited by cortical bone: a pilot study. Nana AD Clin. Orthop. Relat. Res. 471(10), 3147-8, (2013)

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A fluorescent responsive hybrid nanogel for closed-loop control of glucose. Wu W, Chen S, Hu Y, et al. J. Diabetes Sci. Technol. 6(4), 892-901, (2012)

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Amine-reactive polymers synthesized by RAFT polymerization using an azlactone functional trithiocarbonate RAFT agent. Ho HT, Leroux F, Pascual S, et al. Macromol. Rapid Commun. 33(20), 1753-8, (2012)

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A smart nanofiber web that captures and releases cells. Kim YJ, Ebara M, and Aoyagi T Angew. Chem. Int. Ed. Engl. 51(42), 10537-41, (2012)

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Polymerizing nonfluorescent monomers without incorporating any fluorescent agent produces strong fluorescent polymers. Yan JJ, Wang ZK, Lin XS, et al. Adv. Mater. 24(41), 5617-24, (2012)

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Protein crystallization and biosensor applications of hydrogel-based molecularly imprinted polymers. Reddy SM, Phan QT, El-Sharif H, et al. Biomacromolecules 13(12), 3959-65, (2012)

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Novel semi-interpenetrating hydrogel networks with enhanced mechanical properties and thermoresponsive engineered drug delivery, designed as bioactive endotracheal tube biomaterials. Jones DS, Andrews GP, Caldwell DL, et al. Eur. J. Pharm. Biopharm. 82(3), 563-71, (2012)

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Integrated system for temperature-controlled fast protein liquid chromatography comprising improved copolymer modified beaded agarose adsorbents and a travelling cooling zone reactor arrangement. Müller TK, Cao P, Ewert S, et al. J. Chromatogr. A 1285, 97-109, (2013)

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Intermolecular approach to metal ion indicators based on polymer phase transitions coupled to fluorescence resonance energy transfer. Yao S, Jones AM, Du J, et al. Analyst 137(20), 4734-41, (2012)

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A pH gated, glucose-sensitive nanoparticle based on worm-like mesoporous silica for controlled insulin release. Sun L, Zhang X, Zheng C, et al. J. Phys. Chem. B 117(14), 3852-60, (2013)

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Thermoresponsive chitosan/N-isopropylacrylamide copolymer through atom transfer radical polymerization. Ifuku S, Miwa T, Morimoto M, et al. Int. J. Biol. Macromol. 52, 14-9, (2013)

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Magnetocaloric effect in magnetothermally-responsive nanocarriers for hyperthermia-triggered drug release. Li J, Qu Y, Ren J, et al. Nanotechnology 23(50), 505706, (2012)

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N-isopropylacrylamide-modified polyethylenimines as effective gene carriers. Tian H, Li F, Chen J, et al. Macromol. Biosci. 12(12), 1680-8, (2012)

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Injectable hydrogel as stem cell scaffolds from the thermosensitive terpolymer of NIPAAm/AAc/HEMAPCL. Lian S, Xiao Y, Bian Q, et al. Int. J. Nanomedicine 7, 4893-905, (2012)

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Shell cross-linking of cyclodextrin-based micelles via supramolecular chemistry for the delivery of drugs. Yhaya F, Binauld S, Kim Y, et al. Macromol. Rapid Commun. 33(21), 1868-74, (2012)

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Dynamics in N-isopropylacrylamide-acrylic acid copolymer aqueous solution from mechanical spectroscopy. Wang H, Wu X, Liu CS, et al. J. Phys. Chem. B 116(45), 13411-5, (2012)

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In situ forming, resorbable graft copolymer hydrogels providing controlled drug release. Overstreet DJ, Huynh R, Jarbo K, et al. J. Biomed. Mater. Res. A 101(5), 1437-46, (2013)

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Impact of heating method on the flocculation process using thermosensitive polymer. Lemanowicz M, Kuźnik W, Gibas M, et al. Water Res. 46(13), 4091-8, (2012)

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Distribution of locally delivered antimicrobials is limited by cortical bone: a pilot study. Odgers R, Jarbo K, McLaren A, et al. Clin. Orthop. Relat. Res. 471(10), 3141-6, (2013)

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Fabrication and aggregation of thermoresponsive glucose-functionalized double hydrophilic copolymers. Lou SF, Zhang H, Williams GR, et al. Colloids Surf. B Biointerfaces 105, 180-6, (2013)

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Peptide/protein separation with cationic polymer brush nanosponges for MALDI-MS analysis. Mitrovic B, Eastwood S, Wong V, et al. Langmuir 29(2), 696-700, (2013)

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Controlled release of lipase from Candida rugosa loaded into hydrogels of N-isopropylacrylamide and itaconic acid. Milašinović N, Knežević-Jugović Z, Milosavljević N, et al. Int. J. Pharm. 436(1-2), 332-40, (2012)

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Volume transition and adhesion force of nanosized bifunctional spherical polyelectrolyte brushes observed by dynamic light scattering and atomic force microscopy. Huang S, Guo X, Li L, et al. J. Phys. Chem. B 116(33), 10079-88, (2012)

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Thermally programmable pH buffers. Van Gough D, Bunker BC, Roberts ME, et al. ACS Appl. Mater. Interfaces 4(11), 6247-51, (2012)

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Use of poly(N-isopropylacrylamide) nanohydrogels for the controlled release of pimaricin in active packaging. Fuciños C, Guerra NP, Teijón JM, et al. J. Food Sci. 77(7), N21-8, (2012)

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Effect of composition interactions on the dose response of an N-isopropylacrylamide gel dosimeter. Chang YJ and Hsieh BT PLoS ONE 7(10), e44905, (2012)

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Temperature-sensitive hydrogels by graft polymerization of chitosan and N-isopropylacrylamide for drug release. Spizzirri UG, Iemma F, Cirillo G, et al. Pharm. Dev. Technol. 18(5), 1026-34, (2013)

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Synthesis of two thermo-responsive copolymers forming recyclable aqueous two-phase systems and its application in cefprozil partition. Hou D and Cao X J. Chromatogr. A 1349, 30-6, (2014)

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Beil. 4,IV,517

FT-IR 2 (1), 1266:C / Structure Index 1, 135:D:3

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