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417467 Aldrich

Triethyl 2-phosphonobutyrate

98%

Synonym: α-Diethylphosphonobutanoic acid ethyl ester, Ethyl 2-(diethoxyphosphoryl)butanoate, NSC 22423

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Horner-Wadsworth-Emmons Reagents, Olefination, Synthetic Reagents More...
InChI Key   GYUCVQSNZFRDRL-UHFFFAOYSA-N
assay   98%
refractive index   n20/D 1.432(lit.)
bp   152-154 °C/14 mmHg(lit.)
density   1.064 g/mL at 25 °C(lit.)

Description

Packaging

5 mL in glass bottle

Application

Reactant for preparation of:
• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)
• α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates
• Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)
• Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis

Price and Availability


Cross-Coupling Guide
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles
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