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41996 Aldrich

1-Hydroxy-7-azabenzotriazole solution

~0.6 M in DMF

Synonym: 3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt

  • CAS Number 39968-33-7

  • Empirical Formula (Hill Notation) C5H4N4O

  • Molecular Weight 136.11

  •  Beilstein Registry Number 1211115

  •  MDL number MFCD00210053

  •  PubChem Substance ID 57650093

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Properties

Related Categories Active Esters/Additives, Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry,
InChI Key   FPIRBHDGWMWJEP-UHFFFAOYSA-N
concentration   ~0.6 M in DMF
impurities   <1.0% water
refractive index   n20/D 1.441
density   0.973 g/mL at 20 °C

Description

Other Notes

Coupling additive for efficient racemization-free coupling in peptide synthesis; segment coupling.

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Safety & Documentation

Safety Information

Signal word 
Danger
Precautionary statements 
RIDADR 
UN 1993C 3 / PGIII
WGK Germany 
3
Flash Point(F) 
136.4 °F
Flash Point(C) 
58 °C
Protocols & Articles

Articles

COMU—Safer and More Efficient Peptide Coupling Reagent

Proteins and peptides are ubiquitous in all living systems. The chemical synthesis of peptidic structures for scientific research or drug discovery relies heavily on efficient coupling reagents. This...
Dr. Matthias Junkers
Aldrich Chemfiles, 2010 Volume 10 Article 1
Keywords: Calorimetry, Coupling reactions, Drug discovery, Epimerizations, Methods, Microwave synthesis, Peptide synthesis, Protocols, Racemizations, Reductions, Search, Sequences, Solid phase peptide synthesis, Solvents

Related Content

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

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