|Related Categories||Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines More...|
|density||1.158 g/mL at 25 °C(lit.)|
5, 25 g in glass bottle
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 421235.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
|Flash Point(F)||>230 °F|
|Flash Point(C)||>110 °C|
Trifluoroborates are air-stable alternatives to boronic acids in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions.1,2 They are more robust, easier to handle, and less prone to protodeboron...
Aldrich ChemFiles 2005, 5.5, 11.
Keywords: Catalysis, Coupling reactions, Cross couplings
The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone. Zhu L, Yang X, Zhou J, et al. Food Chem. Toxicol. 51, 396-403, (2013)
Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action. Vaidya AH, Rosenthal DI, Lang W, et al. Methods Find. Exp. Clin. Pharmacol. 27(4), 245-55, (2005)
Inhibitory effects of the 5-HT(1A) receptor agonist buspirone on stress-induced hyperglycemia in mice: involvement of insulin and a buspirone metabolite, 1-(2-pyrimidinyl)piperazine (1-PP). Sugimoto Y, Takashima N, Noma T, et al. Biol. Pharm. Bull. 28(4), 733-5, (2005)
Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone. Laine K, Ahokoski O, Huupponen R, et al. Eur. J. Clin. Pharmacol. 59(10), 761-6, (2003)
Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats. Zuideveld KP, Rusiç-Pavletiç J, Maas HJ, et al. J. Pharmacol. Exp. Ther. 303(3), 1130-7, (2002)
Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Gobert A, Rivet JM, Cistarelli L, et al. Neuroscience 93(4), 1251-62, (1999)
Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects. von Moltke LL, Greenblatt DJ, Grassi JM, et al. Psychopharmacology 140(3), 293-9, (1998)
Pharmacokinetics and CNS pharmacodynamics of the 5-HT1A agonist buspirone in humans following acute L-tryptophan depletion challenge. Jagannathan V and Venitz J Methods Find. Exp. Clin. Pharmacol. 19(5), 351-62, (1997)
Simultaneous quantitation of buspirone and its major metabolite 1-(2-pyrimidinyl)piperazine in human plasma by high-performance liquid chromatography with coulometric detection. Odontiadis J and Franklin M J. Pharm. Biomed. Anal. 14(3), 347-51, (1996)
The azapirone metabolite 1-(2-pyrimidinyl)piperazine depresses excitatory synaptic transmission in the hippocampus of the alert rat via 5-HT1A receptors. Manahan-Vaughan D, Anwyl R, and Rowan MJ Eur. J. Pharmacol. 294(2-3), 617-24, (1995)
The influence of buspirone, and its metabolite 1-PP, on the activity of paroxetine in the mouse light/dark paradigm and four plates test. Hascoët M, Bourin M, and Nic Dhonnchadha BA Pharmacol. Biochem. Behav. 67(1), 45-53, (2000)
Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone. Kivistö KT, Lamberg TS, and Neuvonen PJ Pharmacol. Toxicol. 84(2), 94-7, (1999)
Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine. Berlin I, Chalon S, Payan C, et al. Br. J. Clin. Pharmacol. 39(3), 243-9, (1995)
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