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430471 Aldrich

Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 50,000-75,000

Synonym: Lactel® B6001-1, PLGA

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Properties

Related Categories 3D Printing Materials for Research and Development, 85:15 (Lactide:Glycolide), Biodegradable Polymers, Biodegradeable Polymers for 3D Printing, Cell Culture,
form   amorphous
feed ratio   lactide:glycolide 85:15
mol wt   Mw 50,000-75,000
degradation timeframe   <6 months
viscosity   0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)
transition temp   Tg 45-50 °C
solubility   ethyl acetate, chloroform, acetone and THF: soluble
storage temp.   2-8°C

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1, 5 g in glass bottle

Physical form

Biocompatible, biodegradable polymer.

Application

PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone. Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

General description

Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.

Legal Information

Lactel is a registered trademark of Durect Corp.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg
Protocols & Articles

Articles

3D Printing of Carbon Fiber-Reinforced Composites

3D printing is a type of additive manufacturing that can be used to rapidly fabricate components with highly customizable geometries, most typically using a layer-by-layer fabrication process. 3D pri...
Zhenyu Bo* (Ph.D Candidate at Northwestern University) and Jia Choi*, PhD, Product Manager


*Materials Science Product Management Team, MilliporeSigma, Milwaukee, WI.
Keywords: Deposition, Nanomaterials, Nanotubes

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been w...
Anna Musyanovych and Katharina Landfester
Material Matters 2012 v7, n3
Keywords: Adhesion, Antitumor agents, Applications, Biomaterials, Central Nervous System, Degradations, Deposition, Diffusion, Evaporation, Growth factors, Melting, Methods, Microscopy, Precipitation, Purification, Reductions, Scanning electron microscopy, Type

Biodegradable Polyester-based Nanoparticle Formation by Miniemulsion Technique

Anna Musyanovych and Katharina Landfester Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany Email: landfest@mpip-mainz.mpg.de
Keywords: Adhesion, Antitumor agents, Biomaterials, Central Nervous System, Degradations, Deposition, Diffusion, Evaporation, Growth factors, Melting, Microscopy, Precipitation, Purification, Reductions, Scanning electron microscopy

Biomaterials Tutorial

Biocompatible Polymers Biodegradable Polymers Crosslinkers Biocompatible Inorganic Materials Supramolecular Chemistry
Keywords: Agriculture, Antimicrobials, Biomaterials, Ceramics, Chromatography, Cosmetics, Degradations, Diffusion, Environmental, Genomics, Germination, Nanomaterials, Oxidations, Petrochemical, Pharmaceutical, Polymerization reactions, Proteomics, Reductions

Bioprinting for Tissue Engineering and Regenerative Medicine

Chi-Chun Pan,1,2 Arnaud Bruyas,1 Yunzhi Peter Yang1,3,4 Departments of 1Orthopedic Surgery, 2Mechanical Engineering, 3Materials Science and Engineering, and 4Bioengineering Stanford University, 300 P...
Chi-Chun Pan, Arnaud Bruyas, Yunzhi Peter Yang
Material Matters, 2016, 11.2
Keywords: Biomaterials, Cancer, Cell attachment, Clinical, Deposition, Growth factors, Pharmaceutical

Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine

Yadong Wang,1 Steven Lu,2 Peter Gabriele,2 Jeremy J. Harris2* 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 USA 2Research and Development, The Secant Group, LLC, Telfo...
Yadong Wang, Steven Lu, Peter Gabriele, Jeremy J. Harris
Material Matters, 2016, 11.3
Keywords: Antimicrobials, Biomaterials, Building blocks, Cardiovascular, Clinical, Confocal microscopy, Degradations, Ligands, Metabolites, Microscopy, Oxidations, Pharmaceutical, Polymerization reactions, Positron Emission Tomography, Reversed-phase chromatography, Solvents, Titrations, transformation

RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

The ability for synthetic polymers to degrade in a controlled manner was developed for environmental reasons in the late 1960s. Interest in utilizing biodegradable polymers for biomedical application...
Keywords: Cancer, Degradations, Diagnostic, Diffusion, Environmental, Evaporation, Hormones, PEGylations, Polymerization reactions, Reductions, Ring-opening polymerization, Separation

Peer-Reviewed Papers
15

References

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