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430471 Aldrich

Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 50,000-75,000

Synonym: Lactel® B6001-1, PLGA

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Properties

Related Categories 3D Printing Materials for Research and Development, 85:15 (Lactide:Glycolide), Biodegradable Polymers, Biodegradeable Polymers for 3D Printing, Cell Culture,
form   amorphous
feed ratio   lactide:glycolide 85:15
mol wt   Mw 50,000-75,000
degradation timeframe   <6 months
viscosity   0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)
transition temp   Tg 45-50 °C
solubility   ethyl acetate, chloroform, acetone and THF: soluble
storage temp.   2-8°C

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1, 5 g in glass bottle

Physical form

Biocompatible, biodegradable polymer.

Application

PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone. Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

General description

Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.

Legal Information

Lactel is a registered trademark of Durect Corp.

Price and Availability


3D Printing

The Future of Bioimaging

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
What are the end groups of Product No. 430471 (Poly(DL-lactide-co-glycolide)?
Product 430471 has a dodecyl (12 carbon) ester on one end of the polymer chain and a hydroxyl end group on the other.
What is the density of Product No. 430471 Poly(DL-lactide-co-glycolide)?
According to the manufacturer, product 430471 has a theoretical density of 1.27g/mL.
How is this Product No. 430471 synthesized (Poly(DL-lactide-co-glycolide)?
To synthesize product 430471, 1-dodecanol is used as an initiator and stannous octoate is used as a catalyst to start the ring opening polymerization of D,L-lactide and glycolide monomers.
What is the tensile strength of Product No. 403471 Poly(DL-lactide-co-glycolide)?
Product 430471 has a tensile strength of 6000 - 8000 psi, with an elongation of 3-10%.
Is Product No. 403471 a resorbable polymer?
Yes, Product No. 430471 has a resorption time of 5-6 months.
Show more questions
Protocols & Articles

Articles

3D Printing of Carbon Fiber-Reinforced Composites

3D printing is a type of additive manufacturing that can be used to rapidly fabricate components with highly customizable geometries, most typically using a layer-by-layer fabrication process. 3D pri...
Zhenyu Bo* (Ph.D Candidate at Northwestern University) and Jia Choi*, PhD, Product Manager


*Materials Science Product Management Team, MilliporeSigma, Milwaukee, WI.
Keywords: Deposition, Nanomaterials, Nanotubes

Biodegradable Aliphatic Polyesters for Drug Delivery

1Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080 2Department of Bioengineering, University of Texas at Dallas, Richardson, TX 75080 *Email: mihaela@utdal...
Vasanthy Karmegam,1 Pooneh Soltantabar,2 Erika Joy L. Calubaquib,1 Ruvanthi N. Kularatne,1 Mihaela C. Stefan1,2*
Material Matters, 2017, 12.2
Keywords: Bacterial conjugations, Biochemistry, Cancer, Catalysis, Clinical, Degradations, Electron spin resonance, Polymerization reactions, Reductions, Ring-opening polymerization, Solvents, Vitamins

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been w...
Anna Musyanovych and Katharina Landfester
Material Matters 2012 v7, n3
Keywords: Adhesion, Antitumor agents, Applications, Biomaterials, Central Nervous System, Degradations, Deposition, Diffusion, Evaporation, Growth factors, Melting, Methods, Microscopy, Precipitation, Purification, Reductions, Scanning electron microscopy, Type

Biodegradable Polyester-based Nanoparticle Formation by Miniemulsion Technique

Anna Musyanovych and Katharina Landfester Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany Email: landfest@mpip-mainz.mpg.de
Keywords: Adhesion, Antitumor agents, Biomaterials, Central Nervous System, Degradations, Deposition, Diffusion, Evaporation, Growth factors, Melting, Microscopy, Precipitation, Purification, Reductions, Scanning electron microscopy

Biomaterials Tutorial

Biocompatible Polymers Biodegradable Polymers Crosslinkers Biocompatible Inorganic Materials Supramolecular Chemistry
Keywords: Agriculture, Antimicrobials, Biomaterials, Ceramics, Chromatography, Cosmetics, Degradations, Diffusion, Environmental, Genomics, Germination, Nanomaterials, Oxidations, Petrochemical, Pharmaceutical, Polymerization reactions, Proteomics, Reductions

Bioprinting for Tissue Engineering and Regenerative Medicine

Chi-Chun Pan,1,2 Arnaud Bruyas,1 Yunzhi Peter Yang1,3,4 Departments of 1Orthopedic Surgery, 2Mechanical Engineering, 3Materials Science and Engineering, and 4Bioengineering Stanford University, 300 P...
Chi-Chun Pan, Arnaud Bruyas, Yunzhi Peter Yang
Material Matters, 2016, 11.2
Keywords: Biomaterials, Cancer, Cell attachment, Clinical, Deposition, Growth factors, Pharmaceutical

Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine

Yadong Wang,1 Steven Lu,2 Peter Gabriele,2 Jeremy J. Harris2* 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 USA 2Research and Development, The Secant Group, LLC, Telfo...
Yadong Wang, Steven Lu, Peter Gabriele, Jeremy J. Harris
Material Matters, 2016, 11.3
Keywords: Antimicrobials, Biomaterials, Building blocks, Cardiovascular, Clinical, Confocal microscopy, Degradations, Ligands, Metabolites, Microscopy, Oxidations, Pharmaceutical, Polymerization reactions, Positron Emission Tomography, Reversed-phase chromatography, Solvents, Titrations, transformation

RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

The ability for synthetic polymers to degrade in a controlled manner was developed for environmental reasons in the late 1960s. Interest in utilizing biodegradable polymers for biomedical application...
Keywords: Cancer, Degradations, Diagnostic, Diffusion, Environmental, Evaporation, Hormones, PEGylations, Polymerization reactions, Reductions, Ring-opening polymerization, Separation

Peer-Reviewed Papers
15

References

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