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445088 Aldrich

mono-Ethyl malonate

Synonym: (Ethoxycarbonyl)acetic acid, 3-Ethoxy-3-oxopropanoic acid, Ethyl hydrogen malonate, Ethyl malonate, Monoethyl hydrogen malonate

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Properties

Related Categories Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters,
InChI Key   HGINADPHJQTSKN-UHFFFAOYSA-N
impurities   <10% ethyl malonate, potassium salt
refractive index   n20/D 1.435(lit.)
bp   106.5 °C/3 mmHg(lit.)
density   1.119 g/mL at 25 °C(lit.)

Description

Packaging

5 g in glass bottle

Application

Reactant for:
• Preparation of tetramic acids via Dieckmann ring closure
• Organocatalytic decarboxylative Doebner-Knoevenagel reactions
• Conjugation to amino-modified oligonucleotides
• Acylation reactions (acylation agent)
• Indole glyoxylamides for potential Prion disease treatment
• Knoevenagel condensation with aldehydes

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 445088.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles

Articles

Knoevenagel Condensation Reaction

The Knoevenagel Condensation Reaction is a classic organic synthesis, described by Emil Knoevenagel in the 1890’s. The Knoevenagel reaction is a modified Aldol Condensation with a nucleophilic additi...
Keywords: Aldol condensation, C-C bond formation, Condensations, Dehydration reaction, Knoevenagel Condensation, Nucleophilic additions, Organic synthesis

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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