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463485 Aldrich

Methyl isonipecotate

technical grade

Synonym: Methyl 4-piperidinecarboxylate

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Properties

Related Categories Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines More...
grade   technical grade
InChI Key   RZVWBASHHLFBJF-UHFFFAOYSA-N
refractive index   n20/D 1.465(lit.)
bp   85-90 °C(lit.)
density   1.06 g/mL at 25 °C(lit.)

Description

Packaging

25, 100 mL in glass bottle

Application

Methyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens.

Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation

Reactant for synthesis of:
Antitubercular agents
Anti-HIV-1 agents
Aminopyrazine inhibitors
Orally available naphthyridine protein kinase D inhibitors
A Scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide

General description

Methyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
3
Flash Point(F) 
192.2 °F
Flash Point(C) 
89 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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