Baicalein

Papers

1. Chem. Pharm. Bull. 39, 1051, (1991)

2. Chem. Pharm. Bull. 38, 3488, (1990)

Absence Of Glutathione Peroxidase 4 Affects Tumor Angiogenesis Through Increased 12/15-lipoxygenase Activity. Schneider, M., et al. Neoplasia 12, 254-63, (2010)

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Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. Alex N Bullock et al J. Med. Chem. 48, 7604-14, (2005)

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The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists. Fang-Rong Chang et al J. Nat. Prod. 68, 971-3, (2005)

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Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3). Rupinder K Lota et al Bioorg. Med. Chem. Lett. 16, 4519-22, (2006)

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Rational Design of Novel, Potent Small Molecule Pan-Selectin Antagonists Kranich, R.; et al. J. Med. Chem. 50, 1101-1115, (2007)

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Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Andrei I Khlebnikov et al Bioorg. Med. Chem. 15, 1749-70, (2007)

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Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Yesseny Vasquez-Martinez et al Bioorg. Med. Chem. 15, 7408-25, (2007)

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Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors. T Hari Babu et al Bioorg. Med. Chem. Lett. 18, 1659-62, (2008)

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Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-kappaB-, AP-1-, or CREB-mediated transcription. Sheng-Teng Huang et al Bioorg. Med. Chem. Lett. 18, 5046-9, (2008)

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2-Aminoresorcinol is a potent alpha-glucosidase inhibitor. Hong Gao et al Bioorg. Med. Chem. Lett. 18, 812-5, (2008)

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Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Ryoko Takasawa et al Bioorg. Med. Chem. 16, 3969-75, (2008)

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Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity. Shixuan Zhang et al Bioorg. Med. Chem. 16, 7128-33, (2008)

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Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Teresa Tarragó et al Bioorg. Med. Chem. 16, 7516-24, (2008)

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QSAR modeling of the interaction of flavonoids with GABA(A) receptor. Pablo R Duchowicz et al Eur. J. Med. Chem. 43, 1593-602, (2008)

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Small-molecule aggregates inhibit amyloid polymerization. Brian Y Feng et al Nat. Chem. Biol. 4, 197-9, (2008)

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Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Yosuke Nishizaki et al Bioorg. Med. Chem. Lett. 19, 4706-10, (2009)

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Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives. Chih-Hua Tseng et al Eur. J. Med. Chem. 44, 3621-6, (2009)

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New inhibitors for expression of IgE receptor on human mast cell. Satoru Tamura et al Bioorg. Med. Chem. Lett. 20, 2299-302, (2010)

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Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides. Ping Wang et al Bioorg. Med. Chem. Lett. 20, 2790-6, (2010)

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Discovery of the inhibitors of tumor necrosis factor alpha with structure-based virtual screening. Hwanho Choi et al Bioorg. Med. Chem. Lett. 20, 6195-8, (2010)

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Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase. Shingo Arioka et al Bioorg. Med. Chem. 18, 1633-40, (2010)

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Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids. Dragan Ami? et al Bioorg. Med. Chem. 18, 28-35, (2010)

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3-Formylchromones: potential antiinflammatory agents. Khalid M Khan et al Eur. J. Med. Chem. 45, 4058-64, (2010)

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Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. Kenyon, V., et al. J. Med. Chem. 54, 5485-5497, (2011)

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Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides. Hyuk Sung Kwon et al Bioorg. Med. Chem. Lett. 21, 4325-8, (2011)

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Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. Hisashi Matsuda et al Bioorg. Med. Chem. 19, 2835-41, (2011)

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Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Vasilis P Androutsopoulos et al Bioorg. Med. Chem. 19, 2842-9, (2011)

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Inhibitors of histone demethylases. Brian Lohse et al Bioorg. Med. Chem. 19, 3625-36, (2011)

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Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Marta Perro Neves et al Eur. J. Med. Chem. 46, 2562-74, (2011)

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Characterization of the baicalein-bovine serum albumin complex without or with Cu2+ or Fe3+ by spectroscopic approaches. Daojin Li et al Eur. J. Med. Chem. 46, 588-99, (2011)

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Comparative studies on interactions of baicalein, baicalin and scutellarin with lysozyme. Yun Huang et al Eur. J. Med. Chem. 46, 6039-45, (2011)

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Discovery of estrogen receptor ? modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. Li Liu et al Bioorg. Med. Chem. Lett. 22, 154-63, (2012)

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4'-Bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-?B signaling pathway in RAW 264.7 macrophages. Dong Han Kim et al Bioorg. Med. Chem. Lett. 22, 700-5, (2012)

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Merck 14,942

Beil. 18,V,4,569