|Related Categories||B, Bioactive Small Molecules, Building Blocks, C15 to C38, Cancer Research,|
mouse ... Hexa(15211)|
rat ... Alox15(81639), Alox5(25290)
The flavonoid component of Nepalese and Sino-Japanese crude drugs.1,2 Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.
100, 500 mg in glass bottle
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
1. Chem. Pharm. Bull. 39, 1051, (1991)
2. Chem. Pharm. Bull. 38, 3488, (1990)
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3). Rupinder K Lota et al Bioorg. Med. Chem. Lett. 16, 4519-22, (2006)
Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Andrei I Khlebnikov et al Bioorg. Med. Chem. 15, 1749-70, (2007)
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Yesseny Vasquez-Martinez et al Bioorg. Med. Chem. 15, 7408-25, (2007)
Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-kappaB-, AP-1-, or CREB-mediated transcription. Sheng-Teng Huang et al Bioorg. Med. Chem. Lett. 18, 5046-9, (2008)
Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Marta Perro Neves et al Eur. J. Med. Chem. 46, 2562-74, (2011)
Discovery of estrogen receptor ? modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. Li Liu et al Bioorg. Med. Chem. Lett. 22, 154-63, (2012)
4'-Bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-?B signaling pathway in RAW 264.7 macrophages. Dong Han Kim et al Bioorg. Med. Chem. Lett. 22, 700-5, (2012)
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