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484318 Aldrich

Ethylene glycol monophenyl ether

≥90%

Synonym: 2-Phenoxyethanol, DOWANOL® EPh, Phenylglycol

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Properties

Related Categories Alcohols, Building Blocks, C7 to C8, Chemical Synthesis, Ethers,
vapor density   4.8 (vs air)
vapor pressure   0.01 mmHg ( 20 °C)
assay   ≥90%
impurities   ≤0.5% Phenol
  <10% diethylene glycol phenyl ether
refractive index   n20/D 1.537(lit.)
bp   247 °C(lit.)
mp   11-13 °C(lit.)
density   1.102 g/mL at 25 °C(lit.)

Description

Packaging

1 L in poly bottle

18 L in steel drum

Legal Information

Product of Dow Chemical
™Trademark of The Dow Chemical Company

DOWANOL is a registered trademark of The Dow Chemical Company or an affiliated company of Dow

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Safety Information

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GHS07  GHS07
Signal word 
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Hazard statements 
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WGK Germany 
1
RTECS 
KM0350000

Protocols & Articles

Peer-Reviewed Papers

References

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Non-fragrance allergens in specific cosmetic products. Travassos AR, Claes L, Boey L, et al. Contact Dermatitis 65(5), 276-85, (2011)

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Methylisothiazolinone contact allergy and dose-response relationships. Lundov MD, Zachariae C, and Johansen JD Contact Dermatitis 64(6), 330-6, (2011)

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[Analysis of preservatives used in cosmetic products: salicylic acid, sodium benzoate, sodium dehydroacetate, potassium sorbate, phenoxyethanol, and parabens]. Ikarashi Y, Uchino T, and Nishimura T Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho. Hokoku. (128), 85-90, (2010)

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Pseudomonas aeruginosa PAO1 adapted to 2-phenoxyethanol shows cross-resistance to dissimilar biocides and increased susceptibility to antibiotics. Abdel Malek SM and Badran YR Folia Microbiol. (Praha) 55(6), 588-92, (2010)

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2-phenoxyethanol-induced contact urticaria and anaphylaxis. Núñez Orjales R, Carballas Vázquez C, Carballada González F, et al. J. Investig. Allergol. Clin. Immunol. 20(4), 354-5, (2010)

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Contact urticaria due to phenoxyethanol in an aftershave. Lujan D, Hernandez-Machin B, Peñate Y, et al. Dermatitis 20(4), E10, (2009)

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[Simultaneous determination of adapalene, 2-phenoxyethanol and methyl-4-hydroxybenzoate in adapalene gels using high performance liquid chromatography]. Zhang C, Zhao Y, Han C, et al. Se Pu 26(5), 640-2, (2008)

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Comparison of the antiseptic efficacy of tissue-tolerable plasma and an octenidine hydrochloride-based wound antiseptic on human skin. Lademann J, Richter H, Schanzer S, et al. Skin Pharmacol. Physiol. 25(2), 100-6, (2012)

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The impact of ethylene glycol monomethyl ether on ovarian function may extend to the next generation in female mice: a preliminary study. Weng SP, Wu TC, Chen SU, et al. Reprod. Toxicol. 29(4), 452-7, (2010)

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2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester. Tripathi SK, Sharma S, Singh HB, et al. Org. Biomol. Chem. 9(2), 581-7, (2011)

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Fragrance material review on 2-phenoxyethanol. Scognamiglio J, Jones L, Letizia CS, et al. Food Chem. Toxicol. 50 Suppl 2, S244-55, (2012)

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Simultaneous determination of eleven preservatives in cosmetics by micellar electrokinetic chromatography. Wang P, Ding X, Li Y, et al. J. AOAC Int. 95(4), 1069-73, (2012)

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Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1. Peter J McNamara et al Antimicrob. Agents Chemother. 53, 1898-906, (2009)

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The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin. Stahl J, Braun M, Siebert J, et al. Int. Wound J. 7(1), 62-9, (2010)

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Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods. Pena Ferreira MR, Costa PC, and Bahia FM Skin Res. Technol. 16(4), 444-9, (2010)

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Allergy to methyldibromoglutaronitrile/phenoxyethanol (Euxyl k 400): regulatory issues, epidemiology, clinical characteristics, and management. Aakhus AE and Warshaw EM Dermatitis 22(3), 127-40, (2011)

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Vibrational spectra and assignments of 2-phenylethanol and 2-phenoxyethanol. Badawi HM Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 82(1), 63-8, (2011)

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The percutaneous permeation of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept®) through skin of different species in vitro. Stahl J, Braun M, Siebert J, et al. BMC Vet. Res. 7, 44, (2011)

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Physiological responses of great sturgeon (Huso huso) to different concentrations of 2-phenoxyethanol as an anesthetic. Shaluei F, Hedayati A, Jahanbakhshi A, et al. Fish Physiol. Biochem. 38(6), 1627-34, (2012)

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Preservative of choice for Prev(e)nar 13™ in a multi-dose formulation. Khandke L, Yang C, Krylova K, et al. Vaccine 29(41), 7144-53, (2011)

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Transdermal evaporation delivery system of praziquantel for schistosomiasis japonicum chemotherapy. Wang L, Zheng X, Fang Y, et al. J. Pharm. Sci. 100(7), 2769-77, (2011)

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Comparison of local metronidazole and a local antiseptic in the treatment of bacterial vaginosis. Novakov Mikic A and Budakov D Arch. Gynecol. Obstet. 282(1), 43-7, (2010)

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MicroRNAs expression in the ethylene glycol monomethyl ether-induced testicular lesion. Fukushima T, Taki K, Ise R, et al. J. Toxicol. Sci. 36(5), 601-11, (2011)

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Efficacy and tolerability of a local acting antiseptic agent in the treatment of vaginal dysbiosis during pregnancy. Briese V, Neumann G, Waldschläger J, et al. Arch. Gynecol. Obstet. 283(3), 585-90, (2011)

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Comparison of the effects of four anaesthetics on haematological and blood biochemical profiles in pikeperch (Sander lucioperca L.). Kristan J, Stara A, Turek J, et al. Neuro Endocrinol. Lett. 33 Suppl 3, 66-71, (2012)

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Immunogenicity of HBV vaccine during stated shelf-life. Gloriani NG, Srinivasa K, Bock HL, et al. Southeast Asian J. Trop. Med. Public Health 41(4), 876-82, (2010)

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Merck 14,7257

Beil. 6,IV,571

Corp MSDS 1 (2), 2750:B / FT-IR 2 (2), 1974:A / FT-IR 1 (1), 1157:A / FT-NMR 1 (2), 395:B / IR-Spectra (2), 616:H / IR-Spectra (3), 697:A / NMR-Reference 2 (1), 956:C / RegBook 1 (1), 1345:J / Sax 6, 2179 / Sigma FT-IR 1 (2), 826:D / Structure Index 1, 208:C:4 / Vapor Phase 3, 1080:A

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