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49920 Aldrich

Glycerol formal

≥98.0% (GC)

  • CAS Number 99569-11-6

  • Empirical Formula (Hill Notation) C4H8O3

  • Molecular Weight 104.10

  •  Beilstein Registry Number 103206

  •  MDL number MFCD10039829

  •  PubChem Substance ID 57651229

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Properties

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InChI Key   JIUMSISXCKWZTA-UHFFFAOYSA-N
assay   ≥98.0% (GC)
contains   ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
composition   5-hydroxy-1,3-dioxane, ~60%
  4-hydroxymethyl-1,3-dioxolane, ~40%
refractive index   n20/D 1.451(lit.)
  n20/D 1.451
bp   192-193 °C(lit.)
density   1.203 g/mL at 25 °C(lit.)

Description

Packaging

100, 500 mL in glass bottle

Application

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

General description

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
3
Flash Point(F) 
199.4 °F
Flash Point(C) 
93 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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