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51126 Aldrich

Hyamine® 1622 solution

4 mM in H2O

Synonym: (Diisobutylphenoxyethoxyethyl)dimethylbenzylammonium chloride solution

Purchase

Description

Packaging

1 L in poly bottle

5 L in poly drum

Application

Hyamine® 1622 solution was used as surfactant to examine its acute toxicity and effect on oxidative stress and cholinesterase (ChE) activity in Dugesia japonica.1 It may be employed as stopping reagent in the improved Eliman procedure for erythrocyte cholinesterase.2

General description

Hyamine® 1622 is a cationic detergent benzethonium chloride.2 Poly(vinyl chloride) membrane ion-selective electrode for the Hyamine 1622 cation has been proposed.3 Its sorption on soil surfaces has been investigated.4 It is widely used in cosmetics and shampoos due to its antimicrobial and cationic surfactant properties.1

Legal Information

Hyamine is a registered trademark of Lonza Group Ltd.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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Safety & Documentation

Safety Information

Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Risk Statements (Europe) 
Safety Statements (Europe) 
61
WGK Germany 
1

Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. Effects of nonionic and ionic surfactants on survival, oxidative stress, and cholinesterase activity of planarian Li M-H. Chemosphere 70(10), 1796-1803, (2008)

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2. Improved Ellman procedure for erythrocyte cholinesterase. George PM and Abernethy MH. Clin. Chem. 29(2), 365-8, (1983)

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3. Poly (vinyl chloride) containing dibenzo-18-crown-6 as an ion-selective membrane for hyamine 1622. Khalil MM, et al. Anal. Lett. 19(7-8), 807-24, (1986)

4. Sorption of anionic surfactants SDS, AOT and cationic surfactant Hyamine 1622 on natural soils. Atay N, et al. Water, Air, Soil Pollut. 136(1-4), 55-68, (2002)

Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein-protein interactions. McFadden MJ, Junop MS, and Brennan JD Anal. Chem. 82(23), 9850-7, (2010)

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Validation of a quantitative NMR method for suspected counterfeit products exemplified on determination of benzethonium chloride in grapefruit seed extracts. Bekiroglu S, Myrberg O, Ostman K, et al. J. Pharm. Biomed. Anal. 47(4-5), 958-61, (2008)

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Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells. Braun S, Werdehausen R, Gaza N, et al. Anesth. Analg. 111(6), 1389-93, (2010)

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Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface. Abu-Rabie P and Spooner N Anal. Chem. 81(24), 10275-84, (2009)

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Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials. Kim DH, Chung HJ, Bleys J, et al. PLoS Negl. Trop. Dis. 3(2), e381, (2009)

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Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines: Imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles. Abhijit Datta Khoje et al Bioorg. Med. Chem. 19, 3483-91, (2011)

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Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution. Kojima N, Morioka T, Urabe D, et al. Bioorg. Med. Chem. 18(24), 8630-41, (2010)

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Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening. Michael J Orsini et al J. Med. Chem. 50, 462-71, (2007)

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Stimulation of suicidal erythrocyte death by benzethonium. Lang E, Jilani K, Zelenak C, et al. Cell Physiol. Biochem. 28(2), 347-54, (2011)

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Ototoxicity of aluminum acetate/benzethonium chloride otic solution in the chinchilla animal model. Pitaro J, Mood ZA, and Daniel SJ Laryngoscope 123(10), 2521-5, (2013)

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Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. Hidemasa Nakaminami et al Antimicrob. Agents Chemother. 54, 4107-11, (2010)

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Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines. Kojima N, Hayashi H, Suzuki S, et al. Bioorg. Med. Chem. Lett. 18(24), 6451-3, (2008)

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The enhancement effect of three sugar alcohols on the fungicidal effect of benzethonium chloride toward Candida albicans. Ichikawa T, Yano Y, Fujita Y, et al. J. Dent. 36(11), 965-8, (2008)

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Acute otitis externa: an update. Schaefer P and Baugh RF Am. Fam. Physician 86(11), 1055-61, (2012)

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A facile synthesis of highly water-soluble, core-shell organo-silica nanoparticles with controllable size via sol-gel process. Du H, Hamilton PD, Reilly MA, et al. J. Colloid. Interface Sci. 340(2), 202-8, (2009)

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Neomycin-phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding. Brandon Findlay et al Bioorg. Med. Chem. Lett. 22, 1499-503, (2012)

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Identification of specific pluripotent stem cell death--inducing small molecules by chemical screening. Conesa C, Doss MX, Antzelevitch C, et al. Stem Cell Rev. 8(1), 116-27, (2012)

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Biocomposite films based on alginate and organically modified clay Tezcan, F., et al. Int. J. Biol. Macromol. 50, 1165, (2012)

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A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. Polireddy K, Khan MM, Chavan H, et al. PLoS ONE 7(7), e40005, (2012)

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Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride. Long Y, Lin Z, Xia M, et al. Toxicol. Appl. Pharmacol. 267(2), 155-66, (2013)

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Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents. Geraldo IM, Gilman A, Shintre MS, et al. Infect. Control Hosp. Epidemiol. 29(8), 736-41, (2008)

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High prevalence of qacA/B carriage among clinical isolates of meticillin-resistant Staphylococcus aureus in Malaysia Shamsudin, M., et al. J. Hosp. Infect. 81, 206, (2012)

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Effects of high-dose major components in oral disinfectants on the cell cycle and apoptosis in primary human gingival fibroblasts in vitro. Nomura Y, Bhawal UK, Nishikiori R, et al. Dent. Mater. J. 29(1), 75-83, (2010)

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Kinetics of 14carbon dioxide excretion from 14C-urea by oral commensal flora Pathak, C.M., et al. J. Gastroenterol. Hepatol. 23, 1603-7, (2008)

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Sensitization prevalence for benzalkonium chloride and benzethonium chloride Dao, H., et al. Dermatitis 23, 162, (2012)

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Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats. Xue Y, Zhang S, Tang M, et al. J. Appl. Toxicol. 32(7), 480-7, (2012)

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Is secondary wavelength always necessary in turbidimetric urine protein measurements? Yilmaz FM, Yilmaz G, and Yücel D Clin. Biochem. 41(7-8), 645-7, (2008)

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Visual and confocal microscopic interpretation of patch tests to benzethonium chloride and benzalkonium chloride. Benjamin B, Chris F, Salvador G, et al. Skin Res. Technol. 18(3), 272-7, (2012)

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Bactericidal activity of topical antiseptics and their gargles against Bordetella pertussis. Suzuki T, Kataoka H, Ida T, et al. J. Infect. Chemother. 18(2), 272-5, (2012)

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[Survey of synthetic disinfectants in grapefruit seed extract and its compounded products]. Sugimoto N, Tada A, Kuroyanagi M, et al. Shokuhin Eiseigaku Zasshi 49(1), 56-62, (2008)

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Merck 14,1074

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